STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (616 aa)    
Predicted Functional Partners:
DCAF1
DDB1 and CUL4 associated factor 1.
   
 
 0.982
RNASEH2B
Ribonuclease H2 subunit B.
      
 0.875
TRIM5
Uncharacterized protein.
   
 
 0.832
SERINC5
Serine incorporator 5.
      
 0.788
CUL4A
Cullin 4A; Belongs to the cullin family.
    
 
 0.787
CD4
T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]
      
 0.723
DDB1
Damage specific DNA binding protein 1.
   
 
 0.719
MX2
Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
     
 0.717
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 
 0.715
APOBEC3A
CMP/dCMP-type deaminase domain-containing protein.
      
 0.709
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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