| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASNS | PHGDH | ENSOCUP00000023543 | ENSOCUP00000004988 | Asparagine synthetase [glutamine-hydrolyzing]. | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.875 |
| ASNS | PSAT1 | ENSOCUP00000023543 | ENSOCUP00000006706 | Asparagine synthetase [glutamine-hydrolyzing]. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.892 |
| ASNS | PSPH | ENSOCUP00000023543 | ENSOCUP00000025907 | Asparagine synthetase [glutamine-hydrolyzing]. | Phosphoserine phosphatase. | 0.683 |
| ASNS | SHMT1 | ENSOCUP00000023543 | ENSOCUP00000017814 | Asparagine synthetase [glutamine-hydrolyzing]. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.478 |
| ASNS | SHMT2 | ENSOCUP00000023543 | ENSOCUP00000019769 | Asparagine synthetase [glutamine-hydrolyzing]. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.746 |
| CTBP2 | PSAT1 | ENSOCUP00000038080 | ENSOCUP00000006706 | C-terminal binding protein 2. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.940 |
| CTBP2 | PSPH | ENSOCUP00000038080 | ENSOCUP00000025907 | C-terminal binding protein 2. | Phosphoserine phosphatase. | 0.654 |
| CTBP2 | SHMT1 | ENSOCUP00000038080 | ENSOCUP00000017814 | C-terminal binding protein 2. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.669 |
| CTBP2 | SHMT2 | ENSOCUP00000038080 | ENSOCUP00000019769 | C-terminal binding protein 2. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.669 |
| ENSOCUP00000044231 | PSAT1 | ENSOCUP00000044231 | ENSOCUP00000006706 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.940 |
| ENSOCUP00000044231 | PSPH | ENSOCUP00000044231 | ENSOCUP00000025907 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Phosphoserine phosphatase. | 0.654 |
| ENSOCUP00000044231 | SHMT1 | ENSOCUP00000044231 | ENSOCUP00000017814 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.669 |
| ENSOCUP00000044231 | SHMT2 | ENSOCUP00000044231 | ENSOCUP00000019769 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.669 |
| GRHPR | PSAT1 | ENSOCUP00000006084 | ENSOCUP00000006706 | Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.892 |
| GRHPR | SHMT1 | ENSOCUP00000006084 | ENSOCUP00000017814 | Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.428 |
| GRHPR | SHMT2 | ENSOCUP00000006084 | ENSOCUP00000019769 | Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.428 |
| HDHD3 | PSAT1 | ENSOCUP00000005061 | ENSOCUP00000006706 | Haloacid dehalogenase like hydrolase domain containing 3. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.883 |
| HDHD3 | PSPH | ENSOCUP00000005061 | ENSOCUP00000025907 | Haloacid dehalogenase like hydrolase domain containing 3. | Phosphoserine phosphatase. | 0.440 |
| HDHD3 | SHMT1 | ENSOCUP00000005061 | ENSOCUP00000017814 | Haloacid dehalogenase like hydrolase domain containing 3. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.614 |
| HDHD3 | SHMT2 | ENSOCUP00000005061 | ENSOCUP00000019769 | Haloacid dehalogenase like hydrolase domain containing 3. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.614 |