SLC11A2 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SLC11A2

Solute carrier family 11 member 2. (589 aa)

Predicted Functional Partners:

SLC11A1

0.913

SLC40A1

0.887

TFRC

0.799

HAMP

0.760

IREB2

0.759

SLC39A14

0.748

CYBRD1

0.746

ACO1

0.708

FTH1

0.702

SLC30A10

0.677

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACO1	FTH1	ENSOCUP00000042092	ENSOCUP00000012121	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family.	Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	0.736
ACO1	HAMP	ENSOCUP00000042092	ENSOCUP00000024006	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family.	Hepcidin antimicrobial peptide.	0.744
ACO1	IREB2	ENSOCUP00000042092	ENSOCUP00000008534	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family.	Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family.	0.525
ACO1	SLC11A2	ENSOCUP00000042092	ENSOCUP00000006709	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family.	Solute carrier family 11 member 2.	0.708
ACO1	SLC40A1	ENSOCUP00000042092	ENSOCUP00000004176	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family.	Solute carrier family 40 member 1.	0.631
ACO1	TFRC	ENSOCUP00000042092	ENSOCUP00000014641	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family.	Transferrin receptor.	0.821
CYBRD1	HAMP	ENSOCUP00000012739	ENSOCUP00000024006	Cytochrome b reductase 1.	Hepcidin antimicrobial peptide.	0.627
CYBRD1	SLC11A2	ENSOCUP00000012739	ENSOCUP00000006709	Cytochrome b reductase 1.	Solute carrier family 11 member 2.	0.746
CYBRD1	SLC40A1	ENSOCUP00000012739	ENSOCUP00000004176	Cytochrome b reductase 1.	Solute carrier family 40 member 1.	0.687
CYBRD1	TFRC	ENSOCUP00000012739	ENSOCUP00000014641	Cytochrome b reductase 1.	Transferrin receptor.	0.504
FTH1	ACO1	ENSOCUP00000012121	ENSOCUP00000042092	Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family.	0.736
FTH1	HAMP	ENSOCUP00000012121	ENSOCUP00000024006	Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	Hepcidin antimicrobial peptide.	0.726
FTH1	IREB2	ENSOCUP00000012121	ENSOCUP00000008534	Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family.	0.693
FTH1	SLC11A2	ENSOCUP00000012121	ENSOCUP00000006709	Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	Solute carrier family 11 member 2.	0.702
FTH1	SLC40A1	ENSOCUP00000012121	ENSOCUP00000004176	Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	Solute carrier family 40 member 1.	0.795
FTH1	TFRC	ENSOCUP00000012121	ENSOCUP00000014641	Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	Transferrin receptor.	0.852
HAMP	ACO1	ENSOCUP00000024006	ENSOCUP00000042092	Hepcidin antimicrobial peptide.	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family.	0.744
HAMP	CYBRD1	ENSOCUP00000024006	ENSOCUP00000012739	Hepcidin antimicrobial peptide.	Cytochrome b reductase 1.	0.627
HAMP	FTH1	ENSOCUP00000024006	ENSOCUP00000012121	Hepcidin antimicrobial peptide.	Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	0.726
HAMP	IREB2	ENSOCUP00000024006	ENSOCUP00000008534	Hepcidin antimicrobial peptide.	Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family.	0.501