STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRYD4SPRY domain containing 4. (207 aa)    
Predicted Functional Partners:
MIP
Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.727
YIF1B
Yip1 interacting factor homolog B, membrane trafficking protein.
   
  
 0.705
ARMCX3
Armadillo repeat containing X-linked 3.
   
 0.663
CPPED1
Calcineurin like phosphoesterase domain containing 1.
      
 0.657
HNRNPUL2
Uncharacterized protein.
     
 0.650
TMEM192
Transmembrane protein 192.
   
  0.630
LYZL6
Lysozyme like 6; Belongs to the glycosyl hydrolase 22 family.
     
 0.619
TMED3
Transmembrane p24 trafficking protein 3.
   
 
 0.613
KDELR1
ER lumen protein-retaining receptor.
      
 0.601
LYZ
Lysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
     
 0.581
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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