Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CDH12Cadherin 12; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)    
Predicted Functional Partners:
CDH8
Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins.
    
0.916
CDH24
Cadherin 24; Cadherins are calcium-dependent cell adhesion proteins.
    
0.905
CTNNB1
Catenin beta 1.
    
 0.881
CTNNA1
Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...]
   
 0.873
CTNNA2
Catenin alpha 2.
   
 0.840
CTNND1
Catenin delta 1.
    
 0.824
CDH7
Cadherin 7; Cadherins are calcium-dependent cell adhesion proteins.
  
 
0.819
CDH11
Cadherin 11; Cadherins are calcium-dependent cell adhesion proteins.
  
 
0.805
CTNNA3
Catenin alpha 3.
   
 0.800
JUP
Junction plakoglobin.
    
  0.780
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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