NR5A1 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

NR5A1

Nuclear receptor subfamily 5 group A member 1. (461 aa)

Predicted Functional Partners:

NR0B1

0.994

PRKACB

0.927

NR0B2

0.879

NCOA2

0.870

WT1

0.854

STAR

0.844

PPARGC1A

0.841

CYP17A1

0.807

SOX9

0.804

CYP11A1

0.776

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP11A1	CYP17A1	ENSOCUP00000023976	ENSOCUP00000015281	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	0.963
CYP11A1	NR0B1	ENSOCUP00000023976	ENSOCUP00000000025	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Nuclear receptor subfamily 0 group B member 1.	0.560
CYP11A1	NR5A1	ENSOCUP00000023976	ENSOCUP00000006784	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Nuclear receptor subfamily 5 group A member 1.	0.776
CYP11A1	SOX9	ENSOCUP00000023976	ENSOCUP00000010009	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	SRY-box transcription factor 9.	0.473
CYP11A1	STAR	ENSOCUP00000023976	ENSOCUP00000002168	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.	0.946
CYP11A1	WT1	ENSOCUP00000023976	ENSOCUP00000005099	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	WT1 transcription factor.	0.417
CYP17A1	CYP11A1	ENSOCUP00000015281	ENSOCUP00000023976	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	0.963
CYP17A1	NR0B1	ENSOCUP00000015281	ENSOCUP00000000025	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Nuclear receptor subfamily 0 group B member 1.	0.506
CYP17A1	NR5A1	ENSOCUP00000015281	ENSOCUP00000006784	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Nuclear receptor subfamily 5 group A member 1.	0.807
CYP17A1	SOX9	ENSOCUP00000015281	ENSOCUP00000010009	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	SRY-box transcription factor 9.	0.476
CYP17A1	STAR	ENSOCUP00000015281	ENSOCUP00000002168	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.	0.906
NCOA2	NR0B1	ENSOCUP00000005169	ENSOCUP00000000025	Nuclear receptor coactivator.	Nuclear receptor subfamily 0 group B member 1.	0.467
NCOA2	NR5A1	ENSOCUP00000005169	ENSOCUP00000006784	Nuclear receptor coactivator.	Nuclear receptor subfamily 5 group A member 1.	0.870
NCOA2	PPARGC1A	ENSOCUP00000005169	ENSOCUP00000034883	Nuclear receptor coactivator.	PPARG coactivator 1 alpha.	0.417
NR0B1	CYP11A1	ENSOCUP00000000025	ENSOCUP00000023976	Nuclear receptor subfamily 0 group B member 1.	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	0.560
NR0B1	CYP17A1	ENSOCUP00000000025	ENSOCUP00000015281	Nuclear receptor subfamily 0 group B member 1.	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	0.506
NR0B1	NCOA2	ENSOCUP00000000025	ENSOCUP00000005169	Nuclear receptor subfamily 0 group B member 1.	Nuclear receptor coactivator.	0.467
NR0B1	NR5A1	ENSOCUP00000000025	ENSOCUP00000006784	Nuclear receptor subfamily 0 group B member 1.	Nuclear receptor subfamily 5 group A member 1.	0.994
NR0B1	SOX9	ENSOCUP00000000025	ENSOCUP00000010009	Nuclear receptor subfamily 0 group B member 1.	SRY-box transcription factor 9.	0.406
NR0B1	STAR	ENSOCUP00000000025	ENSOCUP00000002168	Nuclear receptor subfamily 0 group B member 1.	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.	0.563