Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
STAT6Signal transducer and activator of transcription. (842 aa)    
Predicted Functional Partners:
JAK1
Tyrosine-protein kinase.
   
 0.988
JAK2
Tyrosine-protein kinase.
   
 0.988
EP300
E1A binding protein p300.
    
 0.982
CREBBP
CREB binding protein.
    
 0.979
TYK2
Non-specific protein-tyrosine kinase.
   
 0.978
STAT2
STAT_int domain-containing protein.
   
 0.970
IL4R
Fibronectin type-III domain-containing protein.
   
 0.968
IL4
Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]
    
 0.965
IL13RA1
Interleukin 13 receptor subunit alpha 1.
     
 0.950
IL13RA2
Interleukin 13 receptor subunit alpha 2.
     
 0.940
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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