CST3 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

CST3

Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family. (420 aa)

Predicted Functional Partners:

CTSS

0.786

LGMN

0.777

CTSB

0.760

LOC100347623

0.722

LOC100356256

0.722

LOC100344030

0.722

CTSV

0.721

RANGAP1

0.644

CLU

0.603

B2M

0.601

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CLU	ENSOCUP00000014707	ENSOCUP00000005178	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...]	0.446
B2M	CST3	ENSOCUP00000014707	ENSOCUP00000030610	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	0.601
CLU	B2M	ENSOCUP00000005178	ENSOCUP00000014707	Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...]	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.446
CLU	CST3	ENSOCUP00000005178	ENSOCUP00000030610	Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...]	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	0.603
CST3	B2M	ENSOCUP00000030610	ENSOCUP00000014707	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.601
CST3	CLU	ENSOCUP00000030610	ENSOCUP00000005178	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...]	0.603
CST3	CTSB	ENSOCUP00000030610	ENSOCUP00000032081	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	Cathepsin B; Belongs to the peptidase C1 family.	0.760
CST3	CTSS	ENSOCUP00000030610	ENSOCUP00000009535	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	Cathepsin S; Belongs to the peptidase C1 family.	0.786
CST3	CTSV	ENSOCUP00000030610	ENSOCUP00000038389	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	Cathepsin V; Belongs to the peptidase C1 family.	0.721
CST3	LGMN	ENSOCUP00000030610	ENSOCUP00000004970	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	Legumain.	0.777
CST3	LOC100344030	ENSOCUP00000030610	ENSOCUP00000026218	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.722
CST3	LOC100347623	ENSOCUP00000030610	ENSOCUP00000014610	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.722
CST3	LOC100356256	ENSOCUP00000030610	ENSOCUP00000015334	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.722
CST3	RANGAP1	ENSOCUP00000030610	ENSOCUP00000018760	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	Ran GTPase activating protein 1.	0.644
CTSB	CST3	ENSOCUP00000032081	ENSOCUP00000030610	Cathepsin B; Belongs to the peptidase C1 family.	Cystatin-C; This is a thiol proteinase inhibitor; Belongs to the cystatin family.	0.760
CTSB	CTSS	ENSOCUP00000032081	ENSOCUP00000009535	Cathepsin B; Belongs to the peptidase C1 family.	Cathepsin S; Belongs to the peptidase C1 family.	0.659
CTSB	CTSV	ENSOCUP00000032081	ENSOCUP00000038389	Cathepsin B; Belongs to the peptidase C1 family.	Cathepsin V; Belongs to the peptidase C1 family.	0.684
CTSB	LGMN	ENSOCUP00000032081	ENSOCUP00000004970	Cathepsin B; Belongs to the peptidase C1 family.	Legumain.	0.921
CTSB	LOC100344030	ENSOCUP00000032081	ENSOCUP00000026218	Cathepsin B; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.657
CTSB	LOC100347623	ENSOCUP00000032081	ENSOCUP00000014610	Cathepsin B; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.656