UBA1 protein (Oryctolagus cuniculus) - STRING interaction network

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UBA1

Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity). (1058 aa)

Predicted Functional Partners:

UBB

0.987

TRIP12

0.976

LOC100343047

0.976

UBE2S

0.971

UBE2K

0.954

NEDD8

0.950

UBA6

0.945

UBE2D2

0.938

CDC34

0.930

UBE2R2

0.925

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC34	LOC100343047	ENSOCUP00000019232	ENSOCUP00000035405	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.752
CDC34	NEDD8	ENSOCUP00000019232	ENSOCUP00000002526	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.754
CDC34	TRIP12	ENSOCUP00000019232	ENSOCUP00000034286	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Thyroid hormone receptor interactor 12.	0.774
CDC34	UBA1	ENSOCUP00000019232	ENSOCUP00000007237	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity).	0.930
CDC34	UBA6	ENSOCUP00000019232	ENSOCUP00000011048	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin like modifier activating enzyme 6.	0.783
CDC34	UBB	ENSOCUP00000019232	ENSOCUP00000001111	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]	0.820
CDC34	UBE2D2	ENSOCUP00000019232	ENSOCUP00000026812	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.402
CDC34	UBE2K	ENSOCUP00000019232	ENSOCUP00000005089	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.611
CDC34	UBE2R2	ENSOCUP00000019232	ENSOCUP00000024929	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2 R2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin; Belongs to the ubiquitin-conjugating enzyme family.	0.935
CDC34	UBE2S	ENSOCUP00000019232	ENSOCUP00000011191	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family.	0.535
LOC100343047	CDC34	ENSOCUP00000035405	ENSOCUP00000019232	Ubiquitin-like domain-containing protein.	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	0.752
LOC100343047	NEDD8	ENSOCUP00000035405	ENSOCUP00000002526	Ubiquitin-like domain-containing protein.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.846
LOC100343047	TRIP12	ENSOCUP00000035405	ENSOCUP00000034286	Ubiquitin-like domain-containing protein.	Thyroid hormone receptor interactor 12.	0.738
LOC100343047	UBA1	ENSOCUP00000035405	ENSOCUP00000007237	Ubiquitin-like domain-containing protein.	Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity).	0.976
LOC100343047	UBA6	ENSOCUP00000035405	ENSOCUP00000011048	Ubiquitin-like domain-containing protein.	Ubiquitin like modifier activating enzyme 6.	0.769
LOC100343047	UBB	ENSOCUP00000035405	ENSOCUP00000001111	Ubiquitin-like domain-containing protein.	Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]	0.984
LOC100343047	UBE2D2	ENSOCUP00000035405	ENSOCUP00000026812	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.706
LOC100343047	UBE2K	ENSOCUP00000035405	ENSOCUP00000005089	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.886
LOC100343047	UBE2R2	ENSOCUP00000035405	ENSOCUP00000024929	Ubiquitin-like domain-containing protein.	Ubiquitin-conjugating enzyme E2 R2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin; Belongs to the ubiquitin-conjugating enzyme family.	0.752
LOC100343047	UBE2S	ENSOCUP00000035405	ENSOCUP00000011191	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family.	0.808

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