PEBP1 protein (Oryctolagus cuniculus) - STRING interaction network

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PEBP1

Hippocampal cholinergic neurostimulating peptide; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Belongs to the phosphatidylethanolamine-binding protein family. (187 aa)

Predicted Functional Partners:

ARAF

0.811

RAF1

0.811

BRAF

0.745

YWHAB

0.685

DAP3

0.682

MRPL44

0.682

MIF

0.677

ALOX15

0.675

MRPL46

0.671

MRPL16

0.670

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALOX15	PEBP1	ENSOCUP00000017072	ENSOCUP00000007249	Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...]	Hippocampal cholinergic neurostimulating peptide; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Belongs to the phosphatidylethanolamine-binding protein family.	0.675
ARAF	BRAF	ENSOCUP00000014138	ENSOCUP00000031451	A-Raf proto-oncogene, serine/threonine kinase.	B-Raf proto-oncogene, serine/threonine kinase.	0.964
ARAF	PEBP1	ENSOCUP00000014138	ENSOCUP00000007249	A-Raf proto-oncogene, serine/threonine kinase.	Hippocampal cholinergic neurostimulating peptide; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Belongs to the phosphatidylethanolamine-binding protein family.	0.811
ARAF	YWHAB	ENSOCUP00000014138	ENSOCUP00000034985	A-Raf proto-oncogene, serine/threonine kinase.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.	0.946
BRAF	ARAF	ENSOCUP00000031451	ENSOCUP00000014138	B-Raf proto-oncogene, serine/threonine kinase.	A-Raf proto-oncogene, serine/threonine kinase.	0.964
BRAF	PEBP1	ENSOCUP00000031451	ENSOCUP00000007249	B-Raf proto-oncogene, serine/threonine kinase.	Hippocampal cholinergic neurostimulating peptide; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Belongs to the phosphatidylethanolamine-binding protein family.	0.745
BRAF	RAF1	ENSOCUP00000031451	ENSOCUP00000036596	B-Raf proto-oncogene, serine/threonine kinase.	Raf-1 proto-oncogene, serine/threonine kinase.	0.964
BRAF	YWHAB	ENSOCUP00000031451	ENSOCUP00000034985	B-Raf proto-oncogene, serine/threonine kinase.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.	0.992
DAP3	MRPL16	ENSOCUP00000004139	ENSOCUP00000041313	Death associated protein 3.	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family.	0.851
DAP3	MRPL44	ENSOCUP00000004139	ENSOCUP00000011645	Death associated protein 3.	Mitochondrial ribosomal protein L44.	0.911
DAP3	MRPL46	ENSOCUP00000004139	ENSOCUP00000038762	Death associated protein 3.	Mitochondrial ribosomal protein L46.	0.928
DAP3	PEBP1	ENSOCUP00000004139	ENSOCUP00000007249	Death associated protein 3.	Hippocampal cholinergic neurostimulating peptide; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Belongs to the phosphatidylethanolamine-binding protein family.	0.682
MIF	PEBP1	ENSOCUP00000023295	ENSOCUP00000007249	Macrophage migration inhibitory factor.	Hippocampal cholinergic neurostimulating peptide; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Belongs to the phosphatidylethanolamine-binding protein family.	0.677
MRPL16	DAP3	ENSOCUP00000041313	ENSOCUP00000004139	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family.	Death associated protein 3.	0.851
MRPL16	MRPL44	ENSOCUP00000041313	ENSOCUP00000011645	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family.	Mitochondrial ribosomal protein L44.	0.893
MRPL16	MRPL46	ENSOCUP00000041313	ENSOCUP00000038762	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family.	Mitochondrial ribosomal protein L46.	0.979
MRPL16	PEBP1	ENSOCUP00000041313	ENSOCUP00000007249	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family.	Hippocampal cholinergic neurostimulating peptide; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Belongs to the phosphatidylethanolamine-binding protein family.	0.670
MRPL44	DAP3	ENSOCUP00000011645	ENSOCUP00000004139	Mitochondrial ribosomal protein L44.	Death associated protein 3.	0.911
MRPL44	MRPL16	ENSOCUP00000011645	ENSOCUP00000041313	Mitochondrial ribosomal protein L44.	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family.	0.893
MRPL44	MRPL46	ENSOCUP00000011645	ENSOCUP00000038762	Mitochondrial ribosomal protein L44.	Mitochondrial ribosomal protein L46.	0.969

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