STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GGA2Golgi associated, gamma adaptin ear containing, ARF binding protein 2. (640 aa)    
Predicted Functional Partners:
SORL1
Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic r [...]
    
 
 0.996
RABGEF1
Uncharacterized protein.
    
 0.965
GGA3
Golgi associated, gamma adaptin ear containing, ARF binding protein 3.
  
0.959
RABEP1
Rabaptin, RAB GTPase binding effector protein 1.
   
 0.936
IGF2R
Insulin like growth factor 2 receptor.
    
 
 0.908
SORT1
Sortilin.
    
 
 0.870
RABEP2
Rabaptin, RAB GTPase binding effector protein 2.
    
 0.840
BACE1
Beta-secretase 1; Belongs to the peptidase A1 family.
    
 0.802
ARF1-2
Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.
    
 0.793
CLTCL1
Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.
    
 
 0.789
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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