PALB2 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

PALB2

Partner and localizer of BRCA2. (1182 aa)

Predicted Functional Partners:

BRCA1

0.999

BRCA2

0.999

RAD51C-2

0.998

RAD51

0.994

BRIP1

0.993

BARD1

0.991

AASDH

0.991

RAD51C

0.987

MCAT

0.985

ALG8-2

0.979

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AASDH	MCAT	ENSOCUP00000010497	ENSOCUP00000021054	Aminoadipate-semialdehyde dehydrogenase.	Malonyl-CoA-acyl carrier protein transacylase.	0.674
AASDH	PALB2	ENSOCUP00000010497	ENSOCUP00000007310	Aminoadipate-semialdehyde dehydrogenase.	Partner and localizer of BRCA2.	0.991
ALG8-2	PALB2	ENSOCUP00000027365	ENSOCUP00000007310	NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	Partner and localizer of BRCA2.	0.979
BARD1	BRCA1	ENSOCUP00000001334	ENSOCUP00000003366	BRCA1 associated RING domain 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BARD1	BRCA2	ENSOCUP00000001334	ENSOCUP00000014514	BRCA1 associated RING domain 1.	BRCA2 DNA repair associated.	0.996
BARD1	BRIP1	ENSOCUP00000001334	ENSOCUP00000005779	BRCA1 associated RING domain 1.	BRCA1 interacting protein C-terminal helicase 1.	0.996
BARD1	PALB2	ENSOCUP00000001334	ENSOCUP00000007310	BRCA1 associated RING domain 1.	Partner and localizer of BRCA2.	0.991
BARD1	RAD51	ENSOCUP00000001334	ENSOCUP00000014527	BRCA1 associated RING domain 1.	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...]	0.989
BARD1	RAD51C	ENSOCUP00000001334	ENSOCUP00000001958	BRCA1 associated RING domain 1.	RECA_2 domain-containing protein.	0.931
BARD1	RAD51C-2	ENSOCUP00000001334	ENSOCUP00000017133	BRCA1 associated RING domain 1.	RECA_2 domain-containing protein.	0.930
BRCA1	BARD1	ENSOCUP00000003366	ENSOCUP00000001334	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 associated RING domain 1.	0.999
BRCA1	BRCA2	ENSOCUP00000003366	ENSOCUP00000014514	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA2 DNA repair associated.	0.999
BRCA1	BRIP1	ENSOCUP00000003366	ENSOCUP00000005779	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 interacting protein C-terminal helicase 1.	0.999
BRCA1	PALB2	ENSOCUP00000003366	ENSOCUP00000007310	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Partner and localizer of BRCA2.	0.999
BRCA1	RAD51	ENSOCUP00000003366	ENSOCUP00000014527	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...]	0.999
BRCA1	RAD51C	ENSOCUP00000003366	ENSOCUP00000001958	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RECA_2 domain-containing protein.	0.957
BRCA1	RAD51C-2	ENSOCUP00000003366	ENSOCUP00000017133	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RECA_2 domain-containing protein.	0.957
BRCA2	BARD1	ENSOCUP00000014514	ENSOCUP00000001334	BRCA2 DNA repair associated.	BRCA1 associated RING domain 1.	0.996
BRCA2	BRCA1	ENSOCUP00000014514	ENSOCUP00000003366	BRCA2 DNA repair associated.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BRCA2	BRIP1	ENSOCUP00000014514	ENSOCUP00000005779	BRCA2 DNA repair associated.	BRCA1 interacting protein C-terminal helicase 1.	0.993