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GHR protein (Oryctolagus cuniculus) - STRING interaction network
"GHR" - Growth hormone receptor in Oryctolagus cuniculus
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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GHRGrowth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity) (638 aa)    
Predicted Functional Partners:
JAK2
Janus kinase 2 (1130 aa)
       
  0.972
GH1
Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (187 aa)
       
  0.965
JAK1
Janus kinase 1 (1151 aa)
       
  0.851
PRL
Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation (228 aa)
         
  0.811
STAT5A
Signal transducer and activator of transcription 5A (793 aa)
       
 
  0.782
IGF1
Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exoc [...] (184 aa)
     
   
  0.770
STAT5B
Signal transducer and activator of transcription 5B (786 aa)
       
 
  0.736
LEP
Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal met [...] (167 aa)
     
 
  0.717
TYK2
Tyrosine kinase 2 (1166 aa)
       
  0.691
COCH
Cochlin (551 aa)
     
   
  0.650
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, Oryctolagus cuniculus, domestic rabbit, rabbit, rabbits
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