| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GH1 | GHR | ENSOCUP00000003753 | ENSOCUP00000033529 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). | 0.985 |
| GH1 | JAK1 | ENSOCUP00000003753 | ENSOCUP00000005398 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Tyrosine-protein kinase. | 0.851 |
| GH1 | JAK2 | ENSOCUP00000003753 | ENSOCUP00000014491 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Tyrosine-protein kinase. | 0.895 |
| GH1 | LEP | ENSOCUP00000003753 | ENSOCUP00000008782 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.911 |
| GH1 | LEPR | ENSOCUP00000003753 | ENSOCUP00000014912 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Leptin receptor. | 0.885 |
| GH1 | PRL | ENSOCUP00000003753 | ENSOCUP00000001120 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. | 0.946 |
| GH1 | SOCS2 | ENSOCUP00000003753 | ENSOCUP00000001084 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Suppressor of cytokine signaling 2. | 0.483 |
| GH1 | STAT5A | ENSOCUP00000003753 | ENSOCUP00000024325 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Signal transducer and activator of transcription. | 0.417 |
| GH1 | STAT5B | ENSOCUP00000003753 | ENSOCUP00000004399 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Signal transducer and activator of transcription. | 0.450 |
| GHR | GH1 | ENSOCUP00000033529 | ENSOCUP00000003753 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.985 |
| GHR | JAK1 | ENSOCUP00000033529 | ENSOCUP00000005398 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). | Tyrosine-protein kinase. | 0.928 |
| GHR | JAK2 | ENSOCUP00000033529 | ENSOCUP00000014491 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). | Tyrosine-protein kinase. | 0.992 |
| GHR | LEP | ENSOCUP00000033529 | ENSOCUP00000008782 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.906 |
| GHR | LEPR | ENSOCUP00000033529 | ENSOCUP00000014912 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). | Leptin receptor. | 0.907 |
| GHR | PRL | ENSOCUP00000033529 | ENSOCUP00000001120 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. | 0.972 |
| GHR | SOCS2 | ENSOCUP00000033529 | ENSOCUP00000001084 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). | Suppressor of cytokine signaling 2. | 0.950 |
| GHR | STAT3 | ENSOCUP00000033529 | ENSOCUP00000009494 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). | Signal transducer and activator of transcription. | 0.937 |
| GHR | STAT5A | ENSOCUP00000033529 | ENSOCUP00000024325 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). | Signal transducer and activator of transcription. | 0.940 |
| GHR | STAT5B | ENSOCUP00000033529 | ENSOCUP00000004399 | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). | Signal transducer and activator of transcription. | 0.958 |
| JAK1 | GH1 | ENSOCUP00000005398 | ENSOCUP00000003753 | Tyrosine-protein kinase. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.851 |
