Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
NF1Neurofibromin 1. (2841 aa)    
Predicted Functional Partners:
NRAS
NRAS proto-oncogene, GTPase.
   
 0.978
KRAS
KRAS proto-oncogene, GTPase.
   
 0.971
SPRED1
Sprouty related EVH1 domain containing 1.
   
 0.968
MRAS
Muscle RAS oncogene homolog.
   
 0.919
RRAS2
RAS related 2.
   
 0.919
EGFR
Receptor protein-tyrosine kinase.
    
 
 0.884
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
    
 0.876
SPRED2
Sprouty related EVH1 domain containing 2.
    
 0.870
NF2
Neurofibromin 2.
      
 0.861
NFIB
Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
      
 0.847
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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