| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| A2M | APP | ENSOCUP00000005229 | ENSOCUP00000009130 | Alpha-2-macroglobulin. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.653 |
| A2M | C1S | ENSOCUP00000005229 | ENSOCUP00000012442 | Alpha-2-macroglobulin. | Complement C1s; Belongs to the peptidase S1 family. | 0.537 |
| A2M | CD55 | ENSOCUP00000005229 | ENSOCUP00000045061 | Alpha-2-macroglobulin. | Uncharacterized protein. | 0.431 |
| A2M | CLUL1 | ENSOCUP00000005229 | ENSOCUP00000007480 | Alpha-2-macroglobulin. | Clusterin; Belongs to the clusterin family. | 0.673 |
| A2M | HP | ENSOCUP00000005229 | ENSOCUP00000042923 | Alpha-2-macroglobulin. | Haptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] | 0.802 |
| A2M | LOC100341359 | ENSOCUP00000005229 | ENSOCUP00000010460 | Alpha-2-macroglobulin. | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | 0.403 |
| A2M | VTN | ENSOCUP00000005229 | ENSOCUP00000024132 | Alpha-2-macroglobulin. | Vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. | 0.580 |
| APP | A2M | ENSOCUP00000009130 | ENSOCUP00000005229 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Alpha-2-macroglobulin. | 0.653 |
| APP | C3 | ENSOCUP00000009130 | ENSOCUP00000006634 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | 0.552 |
| APP | CLUL1 | ENSOCUP00000009130 | ENSOCUP00000007480 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Clusterin; Belongs to the clusterin family. | 0.747 |
| APP | HP | ENSOCUP00000009130 | ENSOCUP00000042923 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Haptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] | 0.632 |
| APP | LOC100346672 | ENSOCUP00000009130 | ENSOCUP00000008700 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Uncharacterized protein. | 0.553 |
| C1S | A2M | ENSOCUP00000012442 | ENSOCUP00000005229 | Complement C1s; Belongs to the peptidase S1 family. | Alpha-2-macroglobulin. | 0.537 |
| C1S | C3 | ENSOCUP00000012442 | ENSOCUP00000006634 | Complement C1s; Belongs to the peptidase S1 family. | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | 0.865 |
| C1S | CD55 | ENSOCUP00000012442 | ENSOCUP00000045061 | Complement C1s; Belongs to the peptidase S1 family. | Uncharacterized protein. | 0.722 |
| C1S | CD59 | ENSOCUP00000012442 | ENSOCUP00000036438 | Complement C1s; Belongs to the peptidase S1 family. | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. | 0.715 |
| C1S | CLUL1 | ENSOCUP00000012442 | ENSOCUP00000007480 | Complement C1s; Belongs to the peptidase S1 family. | Clusterin; Belongs to the clusterin family. | 0.715 |
| C1S | LOC100341359 | ENSOCUP00000012442 | ENSOCUP00000010460 | Complement C1s; Belongs to the peptidase S1 family. | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | 0.689 |
| C1S | LOC100346672 | ENSOCUP00000012442 | ENSOCUP00000008700 | Complement C1s; Belongs to the peptidase S1 family. | Uncharacterized protein. | 0.866 |
| C1S | VTN | ENSOCUP00000012442 | ENSOCUP00000024132 | Complement C1s; Belongs to the peptidase S1 family. | Vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. | 0.607 |
