Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADAM12ADAM metallopeptidase domain 12. (904 aa)    
Predicted Functional Partners:
ADAM10
ADAM metallopeptidase domain 10.
   
 
0.756
ADAM17
ADAM metallopeptidase domain 17.
   
 
0.747
MERTK
MER proto-oncogene, tyrosine kinase.
    
 0.611
MAD2L2
Mitotic arrest deficient 2 like 2.
    
 
 0.538
FURIN
Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.
      
 0.524
SH3PXD2A
SH3 and PX domains 2A.
    
 0.513
HBEGF
Heparin binding EGF like growth factor.
      
 0.512
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
    
 0.502
CDH11
Cadherin 11; Cadherins are calcium-dependent cell adhesion proteins.
   
 
 0.458
SNX9
Sorting nexin 9.
    
 
 0.450
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.