DIO1 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DIO1

Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). (249 aa)

Predicted Functional Partners:

THRA

0.692

SLC16A2

0.550

PIP5KL1

0.546

DIO3

0.545

IYD

0.525

TXNRD3

0.519

SELENOO

0.508

SELENOM

0.496

SELENOI

0.492

TG

0.487

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DIO1	DIO3	ENSOCUP00000007619	ENSOCUP00000020198	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	0.545
DIO1	IYD	ENSOCUP00000007619	ENSOCUP00000011535	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Iodotyrosine deiodinase.	0.525
DIO1	PIP5KL1	ENSOCUP00000007619	ENSOCUP00000020277	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Phosphatidylinositol-4-phosphate 5-kinase like 1.	0.546
DIO1	SELENOI	ENSOCUP00000007619	ENSOCUP00000029091	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.492
DIO1	SELENOM	ENSOCUP00000007619	ENSOCUP00000039062	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Sep15_SelM domain-containing protein.	0.496
DIO1	SELENOO	ENSOCUP00000007619	ENSOCUP00000038893	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Selenoprotein O.	0.508
DIO1	SLC16A2	ENSOCUP00000007619	ENSOCUP00000001039	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Solute carrier family 16 member 2.	0.550
DIO1	TG	ENSOCUP00000007619	ENSOCUP00000002619	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	COesterase domain-containing protein.	0.487
DIO1	THRA	ENSOCUP00000007619	ENSOCUP00000032859	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Thyroid hormone receptor alpha.	0.692
DIO1	TXNRD3	ENSOCUP00000007619	ENSOCUP00000026252	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Thioredoxin reductase 3.	0.519
DIO3	DIO1	ENSOCUP00000020198	ENSOCUP00000007619	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	0.545
DIO3	SELENOM	ENSOCUP00000020198	ENSOCUP00000039062	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Sep15_SelM domain-containing protein.	0.525
DIO3	SELENOO	ENSOCUP00000020198	ENSOCUP00000038893	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Selenoprotein O.	0.527
DIO3	SLC16A2	ENSOCUP00000020198	ENSOCUP00000001039	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Solute carrier family 16 member 2.	0.426
IYD	DIO1	ENSOCUP00000011535	ENSOCUP00000007619	Iodotyrosine deiodinase.	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	0.525
IYD	TG	ENSOCUP00000011535	ENSOCUP00000002619	Iodotyrosine deiodinase.	COesterase domain-containing protein.	0.579
PIP5KL1	DIO1	ENSOCUP00000020277	ENSOCUP00000007619	Phosphatidylinositol-4-phosphate 5-kinase like 1.	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	0.546
SELENOI	DIO1	ENSOCUP00000029091	ENSOCUP00000007619	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	0.492
SELENOI	SELENOM	ENSOCUP00000029091	ENSOCUP00000039062	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Sep15_SelM domain-containing protein.	0.816
SELENOI	SELENOO	ENSOCUP00000029091	ENSOCUP00000038893	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Selenoprotein O.	0.865

page 1 of 3

Server load: low (12%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2025

Credits

Access

Info

About