STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RELNUncharacterized protein. (1813 aa)    
Predicted Functional Partners:
VLDLR
Very low-density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).
   
 0.997
ENSOCUP00000046526
Reelin domain-containing protein.
 
     0.942
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
    
 0.917
LRP8
LDL receptor related protein 8.
    
 0.897
ITGA11
Integrin subunit alpha 11; Belongs to the integrin alpha chain family.
    
 0.727
ITGA10
Integrin subunit alpha 10; Belongs to the integrin alpha chain family.
    
 0.720
ITGA7
Integrin subunit alpha 7; Belongs to the integrin alpha chain family.
    
 0.718
ITGB8
Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (By similarity). Required during vasculogenesis (By similarity).
    
 0.715
ITGA9
Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.
    
 0.709
ITGA6
Integrin subunit alpha 6; Belongs to the integrin alpha chain family.
    
 0.697
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.