KLB protein (Oryctolagus cuniculus) - STRING interaction network

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[Homology]

Score

KLB

Klotho beta. (1112 aa)

Predicted Functional Partners:

FGFR1

0.995

FGFR4

0.983

FGF23

0.952

FGF19

0.946

FGF21

0.942

FGFR2

0.847

CYP7A1

0.794

INSR

0.722

IGF1R

0.709

G6PC3

0.709

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP7A1	FGF19	ENSOCUP00000010572	ENSOCUP00000003352	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.788
CYP7A1	FGF21	ENSOCUP00000010572	ENSOCUP00000014754	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.527
CYP7A1	FGFR4	ENSOCUP00000010572	ENSOCUP00000038483	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Fibroblast growth factor receptor.	0.776
CYP7A1	KLB	ENSOCUP00000010572	ENSOCUP00000007846	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Klotho beta.	0.794
FGF19	CYP7A1	ENSOCUP00000003352	ENSOCUP00000010572	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	0.788
FGF19	FGF21	ENSOCUP00000003352	ENSOCUP00000014754	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.571
FGF19	FGF23	ENSOCUP00000003352	ENSOCUP00000024175	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.850
FGF19	FGFR1	ENSOCUP00000003352	ENSOCUP00000041826	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.963
FGF19	FGFR2	ENSOCUP00000003352	ENSOCUP00000034244	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.949
FGF19	FGFR4	ENSOCUP00000003352	ENSOCUP00000038483	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.995
FGF19	IGF1R	ENSOCUP00000003352	ENSOCUP00000012731	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	Tyrosine-protein kinase receptor.	0.874
FGF19	INSR	ENSOCUP00000003352	ENSOCUP00000042281	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	Tyrosine-protein kinase receptor.	0.868
FGF19	KLB	ENSOCUP00000003352	ENSOCUP00000007846	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	Klotho beta.	0.946
FGF21	CYP7A1	ENSOCUP00000014754	ENSOCUP00000010572	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	0.527
FGF21	FGF19	ENSOCUP00000014754	ENSOCUP00000003352	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.571
FGF21	FGF23	ENSOCUP00000014754	ENSOCUP00000024175	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.527
FGF21	FGFR1	ENSOCUP00000014754	ENSOCUP00000041826	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.974
FGF21	FGFR2	ENSOCUP00000014754	ENSOCUP00000034244	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.965
FGF21	FGFR4	ENSOCUP00000014754	ENSOCUP00000038483	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.970
FGF21	IGF1R	ENSOCUP00000014754	ENSOCUP00000012731	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein kinase receptor.	0.902