HLA-DRA protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CD74	ENSOCUP00000030708	ENSOCUP00000003348	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	CD74 molecule.	0.674
CD4	HLA-DMA	ENSOCUP00000030708	ENSOCUP00000015925	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family.	0.906
CD4	HLA-DOB	ENSOCUP00000030708	ENSOCUP00000046550	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Major histocompatibility complex, class II, DO beta.	0.893
CD4	HLA-DPB1	ENSOCUP00000030708	ENSOCUP00000007527	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	RLA class II histocompatibility antigen, DP beta chain.	0.888
CD4	HLA-DQB2	ENSOCUP00000030708	ENSOCUP00000002148	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Major histocompatibility complex, class II, DQ beta 1.	0.880
CD4	HLA-DRA	ENSOCUP00000030708	ENSOCUP00000007861	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Integral membrane protein; Belongs to the MHC class II family.	0.983
CD4	LOC100343144	ENSOCUP00000030708	ENSOCUP00000026229	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.900
CD4	LOC100349667	ENSOCUP00000030708	ENSOCUP00000044229	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Ig-like domain-containing protein.	0.761
CD4	LOC100352672	ENSOCUP00000030708	ENSOCUP00000028564	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.927
CD4	RLA-DMB	ENSOCUP00000030708	ENSOCUP00000021918	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Ig-like domain-containing protein.	0.872
CD74	CD4	ENSOCUP00000003348	ENSOCUP00000030708	CD74 molecule.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.674
CD74	HLA-DMA	ENSOCUP00000003348	ENSOCUP00000015925	CD74 molecule.	Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family.	0.990
CD74	HLA-DOB	ENSOCUP00000003348	ENSOCUP00000046550	CD74 molecule.	Major histocompatibility complex, class II, DO beta.	0.973
CD74	HLA-DPB1	ENSOCUP00000003348	ENSOCUP00000007527	CD74 molecule.	RLA class II histocompatibility antigen, DP beta chain.	0.971
CD74	HLA-DQB2	ENSOCUP00000003348	ENSOCUP00000002148	CD74 molecule.	Major histocompatibility complex, class II, DQ beta 1.	0.975
CD74	HLA-DRA	ENSOCUP00000003348	ENSOCUP00000007861	CD74 molecule.	Integral membrane protein; Belongs to the MHC class II family.	0.999
CD74	LOC100343144	ENSOCUP00000003348	ENSOCUP00000026229	CD74 molecule.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.997
CD74	LOC100349667	ENSOCUP00000003348	ENSOCUP00000044229	CD74 molecule.	Ig-like domain-containing protein.	0.954
CD74	LOC100352672	ENSOCUP00000003348	ENSOCUP00000028564	CD74 molecule.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.961
CD74	RLA-DMB	ENSOCUP00000003348	ENSOCUP00000021918	CD74 molecule.	Ig-like domain-containing protein.	0.967