USP45 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

USP45

Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (813 aa)

Predicted Functional Partners:

USP16

0.851

ERCC1

0.748

USP39

0.669

OTUD6B

0.660

USP26

0.630

USP53

0.622

USP28

0.610

UBB

0.606

KLHL7

0.606

ENSOCUP00000030467

0.606

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOCUP00000030467	ERCC1	ENSOCUP00000030467	ENSOCUP00000024644	Uncharacterized protein.	Uncharacterized protein.	0.478
ENSOCUP00000030467	UBB	ENSOCUP00000030467	ENSOCUP00000001111	Uncharacterized protein.	Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]	0.801
ENSOCUP00000030467	USP16	ENSOCUP00000030467	ENSOCUP00000031799	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.778
ENSOCUP00000030467	USP26	ENSOCUP00000030467	ENSOCUP00000016932	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.411
ENSOCUP00000030467	USP28	ENSOCUP00000030467	ENSOCUP00000027870	Uncharacterized protein.	Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family.	0.761
ENSOCUP00000030467	USP45	ENSOCUP00000030467	ENSOCUP00000007973	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.606
ERCC1	ENSOCUP00000030467	ENSOCUP00000024644	ENSOCUP00000030467	Uncharacterized protein.	Uncharacterized protein.	0.478
ERCC1	UBB	ENSOCUP00000024644	ENSOCUP00000001111	Uncharacterized protein.	Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]	0.478
ERCC1	USP16	ENSOCUP00000024644	ENSOCUP00000031799	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.562
ERCC1	USP45	ENSOCUP00000024644	ENSOCUP00000007973	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.748
KLHL7	USP45	ENSOCUP00000012711	ENSOCUP00000007973	Kelch like family member 7.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.606
OTUD6B	USP26	ENSOCUP00000000191	ENSOCUP00000016932	OTU domain containing 6B.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.555
OTUD6B	USP28	ENSOCUP00000000191	ENSOCUP00000027870	OTU domain containing 6B.	Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family.	0.555
OTUD6B	USP39	ENSOCUP00000000191	ENSOCUP00000029128	OTU domain containing 6B.	Ubiquitin specific peptidase 39.	0.421
OTUD6B	USP45	ENSOCUP00000000191	ENSOCUP00000007973	OTU domain containing 6B.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.660
OTUD6B	USP53	ENSOCUP00000000191	ENSOCUP00000027127	OTU domain containing 6B.	Ubiquitin specific peptidase 53.	0.437
UBB	ENSOCUP00000030467	ENSOCUP00000001111	ENSOCUP00000030467	Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]	Uncharacterized protein.	0.801
UBB	ERCC1	ENSOCUP00000001111	ENSOCUP00000024644	Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]	Uncharacterized protein.	0.478
UBB	USP16	ENSOCUP00000001111	ENSOCUP00000031799	Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.778
UBB	USP26	ENSOCUP00000001111	ENSOCUP00000016932	Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.411

page 1 of 3

Server load: low (30%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About