Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DHTKD1Dehydrogenase E1 and transketolase domain containing 1. (1058 aa)    
Predicted Functional Partners:
DLST
Dihydrolipoamide S-succinyltransferase.
 0.991
GCDH
Glutaryl-CoA dehydrogenase.
   
 
 0.943
LOC100358789
Dihydrolipoyl dehydrogenase.
  
 0.939
DLD
Dihydrolipoyl dehydrogenase.
  
 0.926
SUCLG1
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
  
 0.898
ENSOCUP00000030128
Pyr_redox_2 domain-containing protein.
  
 0.889
AADAT
Aminoadipate aminotransferase.
   
 
 0.887
DLAT
Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.864
CS
Citrate synthase; Belongs to the citrate synthase family.
  
 0.842
PDHX
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
  
 0.824
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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