SHLD1 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

SHLD1

Shieldin complex subunit 1. (254 aa)

Predicted Functional Partners:

SHLD2

0.987

MAD2L2

0.816

DHFR

0.603

HMCES

0.576

RIF1

0.548

CTC1

0.545

ERCC6L2

0.536

MLC1

0.527

UPRT

0.524

LIG4

0.523

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTC1	HMCES	ENSOCUP00000035742	ENSOCUP00000005176	CST telomere replication complex component 1.	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	0.429
CTC1	SHLD1	ENSOCUP00000035742	ENSOCUP00000008036	CST telomere replication complex component 1.	Shieldin complex subunit 1.	0.545
CTC1	SHLD2	ENSOCUP00000035742	ENSOCUP00000003791	CST telomere replication complex component 1.	Shieldin complex subunit 2.	0.775
DHFR	SHLD1	ENSOCUP00000004439	ENSOCUP00000008036	DHFR domain-containing protein.	Shieldin complex subunit 1.	0.603
DHFR	UPRT	ENSOCUP00000004439	ENSOCUP00000015975	DHFR domain-containing protein.	Uracil phosphoribosyltransferase homolog.	0.843
ERCC6L2	LIG4	ENSOCUP00000000394	ENSOCUP00000013516	Uncharacterized protein.	DNA ligase.	0.564
ERCC6L2	SHLD1	ENSOCUP00000000394	ENSOCUP00000008036	Uncharacterized protein.	Shieldin complex subunit 1.	0.536
HMCES	CTC1	ENSOCUP00000005176	ENSOCUP00000035742	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	CST telomere replication complex component 1.	0.429
HMCES	LIG4	ENSOCUP00000005176	ENSOCUP00000013516	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	DNA ligase.	0.409
HMCES	RIF1	ENSOCUP00000005176	ENSOCUP00000022283	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	Replication timing regulatory factor 1.	0.522
HMCES	SHLD1	ENSOCUP00000005176	ENSOCUP00000008036	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	Shieldin complex subunit 1.	0.576
HMCES	SHLD2	ENSOCUP00000005176	ENSOCUP00000003791	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	Shieldin complex subunit 2.	0.597
LIG4	ERCC6L2	ENSOCUP00000013516	ENSOCUP00000000394	DNA ligase.	Uncharacterized protein.	0.564
LIG4	HMCES	ENSOCUP00000013516	ENSOCUP00000005176	DNA ligase.	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	0.409
LIG4	MAD2L2	ENSOCUP00000013516	ENSOCUP00000036253	DNA ligase.	Mitotic arrest deficient 2 like 2.	0.702
LIG4	SHLD1	ENSOCUP00000013516	ENSOCUP00000008036	DNA ligase.	Shieldin complex subunit 1.	0.523
LIG4	SHLD2	ENSOCUP00000013516	ENSOCUP00000003791	DNA ligase.	Shieldin complex subunit 2.	0.544
MAD2L2	LIG4	ENSOCUP00000036253	ENSOCUP00000013516	Mitotic arrest deficient 2 like 2.	DNA ligase.	0.702
MAD2L2	SHLD1	ENSOCUP00000036253	ENSOCUP00000008036	Mitotic arrest deficient 2 like 2.	Shieldin complex subunit 1.	0.816
MAD2L2	SHLD2	ENSOCUP00000036253	ENSOCUP00000003791	Mitotic arrest deficient 2 like 2.	Shieldin complex subunit 2.	0.969