node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY5 | GNB1 | ENSOCUP00000013017 | ENSOCUP00000008676 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | G protein subunit beta 1. | 0.935 |
ADCY5 | GNB3 | ENSOCUP00000013017 | ENSOCUP00000011129 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | G protein subunit beta 3. | 0.936 |
ADCY5 | GNB4 | ENSOCUP00000013017 | ENSOCUP00000000803 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | G protein subunit beta 4. | 0.935 |
ADCY5 | GNB5 | ENSOCUP00000013017 | ENSOCUP00000010220 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.946 |
ADCY5 | GNG3 | ENSOCUP00000013017 | ENSOCUP00000008163 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.949 |
DRD3 | GNB1 | ENSOCUP00000025501 | ENSOCUP00000008676 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. | G protein subunit beta 1. | 0.964 |
DRD3 | GNB3 | ENSOCUP00000025501 | ENSOCUP00000011129 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. | G protein subunit beta 3. | 0.960 |
DRD3 | GNB4 | ENSOCUP00000025501 | ENSOCUP00000000803 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. | G protein subunit beta 4. | 0.964 |
DRD3 | GNB5 | ENSOCUP00000025501 | ENSOCUP00000010220 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.947 |
DRD3 | GNG3 | ENSOCUP00000025501 | ENSOCUP00000008163 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.929 |
GNB1 | ADCY5 | ENSOCUP00000008676 | ENSOCUP00000013017 | G protein subunit beta 1. | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.935 |
GNB1 | DRD3 | ENSOCUP00000008676 | ENSOCUP00000025501 | G protein subunit beta 1. | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. | 0.964 |
GNB1 | GNB3 | ENSOCUP00000008676 | ENSOCUP00000011129 | G protein subunit beta 1. | G protein subunit beta 3. | 0.723 |
GNB1 | GNB4 | ENSOCUP00000008676 | ENSOCUP00000000803 | G protein subunit beta 1. | G protein subunit beta 4. | 0.589 |
GNB1 | GNB5 | ENSOCUP00000008676 | ENSOCUP00000010220 | G protein subunit beta 1. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.586 |
GNB1 | GNG3 | ENSOCUP00000008676 | ENSOCUP00000008163 | G protein subunit beta 1. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.950 |
GNB1 | HTR7 | ENSOCUP00000008676 | ENSOCUP00000046896 | G protein subunit beta 1. | 5-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.961 |
GNB1 | KCNJ6 | ENSOCUP00000008676 | ENSOCUP00000016917 | G protein subunit beta 1. | Potassium voltage-gated channel subfamily J member 6. | 0.971 |
GNB1 | OPRM1 | ENSOCUP00000008676 | ENSOCUP00000031644 | G protein subunit beta 1. | Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. | 0.958 |
GNB1 | PRKCE | ENSOCUP00000008676 | ENSOCUP00000011861 | G protein subunit beta 1. | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] | 0.917 |