| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDH1 | S100A8 | ENSOCUP00000022250 | ENSOCUP00000008245 | Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. | Protein S100; Belongs to the S-100 family. | 0.565 |
| CDH1 | TJP1 | ENSOCUP00000022250 | ENSOCUP00000046568 | Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. | Tight junction protein 1; Belongs to the MAGUK family. | 0.748 |
| ENSOCUP00000010174 | S100A8 | ENSOCUP00000010174 | ENSOCUP00000008245 | Uncharacterized protein. | Protein S100; Belongs to the S-100 family. | 0.553 |
| GRB2 | PTPN11 | ENSOCUP00000042433 | ENSOCUP00000003911 | Growth factor receptor bound protein 2. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.999 |
| GRB2 | S100A8 | ENSOCUP00000042433 | ENSOCUP00000008245 | Growth factor receptor bound protein 2. | Protein S100; Belongs to the S-100 family. | 0.592 |
| PTPN11 | GRB2 | ENSOCUP00000003911 | ENSOCUP00000042433 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | Growth factor receptor bound protein 2. | 0.999 |
| PTPN11 | S100A8 | ENSOCUP00000003911 | ENSOCUP00000008245 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | Protein S100; Belongs to the S-100 family. | 0.655 |
| PTPN11 | TLR4 | ENSOCUP00000003911 | ENSOCUP00000001909 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.474 |
| S100A12 | S100A4 | ENSOCUP00000018611 | ENSOCUP00000007467 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | Protein S100; Belongs to the S-100 family. | 0.471 |
| S100A12 | S100A8 | ENSOCUP00000018611 | ENSOCUP00000008245 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | Protein S100; Belongs to the S-100 family. | 0.986 |
| S100A12 | S100A9 | ENSOCUP00000018611 | ENSOCUP00000007456 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] | 0.798 |
| S100A12 | TLR4 | ENSOCUP00000018611 | ENSOCUP00000001909 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.838 |
| S100A4 | S100A12 | ENSOCUP00000007467 | ENSOCUP00000018611 | Protein S100; Belongs to the S-100 family. | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | 0.471 |
| S100A4 | S100A8 | ENSOCUP00000007467 | ENSOCUP00000008245 | Protein S100; Belongs to the S-100 family. | Protein S100; Belongs to the S-100 family. | 0.565 |
| S100A4 | S100A9 | ENSOCUP00000007467 | ENSOCUP00000007456 | Protein S100; Belongs to the S-100 family. | Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] | 0.431 |
| S100A4 | TLR4 | ENSOCUP00000007467 | ENSOCUP00000001909 | Protein S100; Belongs to the S-100 family. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.498 |
| S100A8 | CDH1 | ENSOCUP00000008245 | ENSOCUP00000022250 | Protein S100; Belongs to the S-100 family. | Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. | 0.565 |
| S100A8 | ENSOCUP00000010174 | ENSOCUP00000008245 | ENSOCUP00000010174 | Protein S100; Belongs to the S-100 family. | Uncharacterized protein. | 0.553 |
| S100A8 | GRB2 | ENSOCUP00000008245 | ENSOCUP00000042433 | Protein S100; Belongs to the S-100 family. | Growth factor receptor bound protein 2. | 0.592 |
| S100A8 | PTPN11 | ENSOCUP00000008245 | ENSOCUP00000003911 | Protein S100; Belongs to the S-100 family. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.655 |