Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ESCO1Establishment of sister chromatid cohesion N-acetyltransferase 1. (842 aa)    
Predicted Functional Partners:
SMC3
Structural maintenance of chromosomes protein.
   
 0.963
RAD21
RAD21 cohesin complex component.
   
 0.929
PDS5A
PDS5 cohesin associated factor A.
   
 0.920
WAPL
WAPL cohesin release factor.
   
 
 0.914
PDS5B
PDS5 cohesin associated factor B.
   
 0.910
ESCO2
Establishment of sister chromatid cohesion N-acetyltransferase 2.
  
  
0.880
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.845
MAU2
MAU2 sister chromatid cohesion factor.
      
 0.815
STAG2
Stromal antigen 2 isoform a (Predicted).
   
 0.813
AANAT
Aralkylamine N-acetyltransferase.
   
  
 0.809
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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