ORMDL3 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ORMDL3

ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)

Predicted Functional Partners:

SPTLC1

0.972

SPTLC3

0.953

SPTLC2

0.930

SPTSSA

0.879

ORM1

0.769

ZPBP2

0.660

ISM1

0.605

SGPP1

0.508

SPTSSB

0.504

SGMS2

0.498

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ISM1	ORMDL3	ENSOCUP00000027835	ENSOCUP00000008326	Isthmin 1.	ORM1-like protein; Negative regulator of sphingolipid synthesis.	0.605
ISM1	SPTLC1	ENSOCUP00000027835	ENSOCUP00000030336	Isthmin 1.	Serine palmitoyltransferase long chain base subunit 1.	0.934
ISM1	SPTSSA	ENSOCUP00000027835	ENSOCUP00000019035	Isthmin 1.	Uncharacterized protein.	0.663
ISM1	SPTSSB	ENSOCUP00000027835	ENSOCUP00000015881	Isthmin 1.	Serine palmitoyltransferase small subunit B.	0.575
ORM1	ORMDL3	ENSOCUP00000003988	ENSOCUP00000008326	Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.	ORM1-like protein; Negative regulator of sphingolipid synthesis.	0.769
ORM1	SPTLC1	ENSOCUP00000003988	ENSOCUP00000030336	Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.	Serine palmitoyltransferase long chain base subunit 1.	0.783
ORM1	SPTLC2	ENSOCUP00000003988	ENSOCUP00000040528	Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.	Serine palmitoyltransferase long chain base subunit 2.	0.619
ORM1	SPTLC3	ENSOCUP00000003988	ENSOCUP00000001125	Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.	Serine palmitoyltransferase long chain base subunit 3.	0.635
ORMDL3	ISM1	ENSOCUP00000008326	ENSOCUP00000027835	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Isthmin 1.	0.605
ORMDL3	ORM1	ENSOCUP00000008326	ENSOCUP00000003988	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.	0.769
ORMDL3	SGMS2	ENSOCUP00000008326	ENSOCUP00000008611	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Sphingomyelin synthase 2.	0.498
ORMDL3	SGPP1	ENSOCUP00000008326	ENSOCUP00000042860	ORM1-like protein; Negative regulator of sphingolipid synthesis.	acidPPc domain-containing protein.	0.508
ORMDL3	SPTLC1	ENSOCUP00000008326	ENSOCUP00000030336	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Serine palmitoyltransferase long chain base subunit 1.	0.972
ORMDL3	SPTLC2	ENSOCUP00000008326	ENSOCUP00000040528	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Serine palmitoyltransferase long chain base subunit 2.	0.930
ORMDL3	SPTLC3	ENSOCUP00000008326	ENSOCUP00000001125	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Serine palmitoyltransferase long chain base subunit 3.	0.953
ORMDL3	SPTSSA	ENSOCUP00000008326	ENSOCUP00000019035	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Uncharacterized protein.	0.879
ORMDL3	SPTSSB	ENSOCUP00000008326	ENSOCUP00000015881	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Serine palmitoyltransferase small subunit B.	0.504
ORMDL3	ZPBP2	ENSOCUP00000008326	ENSOCUP00000040148	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Zona pellucida binding protein 2.	0.660
SGMS2	ORMDL3	ENSOCUP00000008611	ENSOCUP00000008326	Sphingomyelin synthase 2.	ORM1-like protein; Negative regulator of sphingolipid synthesis.	0.498
SGMS2	SGPP1	ENSOCUP00000008611	ENSOCUP00000042860	Sphingomyelin synthase 2.	acidPPc domain-containing protein.	0.964