NLRP12 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NLRP12

NLR family pyrin domain containing 12. (1060 aa)

Predicted Functional Partners:

PYCARD

0.986

NFKB1

0.929

CASP1

0.868

LOC100358658

0.866

IL18

0.718

MEFV

0.710

RIPK2

0.649

IL1B

0.643

TRAF3

0.613

FAF1

0.612

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	IL18	ENSOCUP00000000956	ENSOCUP00000004555	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.998
CASP1	IL1B	ENSOCUP00000000956	ENSOCUP00000021869	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.999
CASP1	MEFV	ENSOCUP00000000956	ENSOCUP00000004286	Uncharacterized protein; Belongs to the peptidase C14A family.	MEFV innate immuity regulator, pyrin.	0.766
CASP1	NFKB1	ENSOCUP00000000956	ENSOCUP00000023734	Uncharacterized protein; Belongs to the peptidase C14A family.	Nuclear factor kappa B subunit 1.	0.468
CASP1	NLRP12	ENSOCUP00000000956	ENSOCUP00000008333	Uncharacterized protein; Belongs to the peptidase C14A family.	NLR family pyrin domain containing 12.	0.868
CASP1	PYCARD	ENSOCUP00000000956	ENSOCUP00000003881	Uncharacterized protein; Belongs to the peptidase C14A family.	PYD and CARD domain containing.	0.999
CASP1	RIPK2	ENSOCUP00000000956	ENSOCUP00000001326	Uncharacterized protein; Belongs to the peptidase C14A family.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.629
CASP1	TRAF3	ENSOCUP00000000956	ENSOCUP00000003184	Uncharacterized protein; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.530
FAF1	NLRP12	ENSOCUP00000042456	ENSOCUP00000008333	Fas associated factor 1.	NLR family pyrin domain containing 12.	0.612
IL18	CASP1	ENSOCUP00000004555	ENSOCUP00000000956	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.998
IL18	IL1B	ENSOCUP00000004555	ENSOCUP00000021869	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.978
IL18	LOC100358658	ENSOCUP00000004555	ENSOCUP00000026479	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.987
IL18	MEFV	ENSOCUP00000004555	ENSOCUP00000004286	Uncharacterized protein.	MEFV innate immuity regulator, pyrin.	0.612
IL18	NFKB1	ENSOCUP00000004555	ENSOCUP00000023734	Uncharacterized protein.	Nuclear factor kappa B subunit 1.	0.928
IL18	NLRP12	ENSOCUP00000004555	ENSOCUP00000008333	Uncharacterized protein.	NLR family pyrin domain containing 12.	0.718
IL18	PYCARD	ENSOCUP00000004555	ENSOCUP00000003881	Uncharacterized protein.	PYD and CARD domain containing.	0.990
IL1B	CASP1	ENSOCUP00000021869	ENSOCUP00000000956	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.999
IL1B	IL18	ENSOCUP00000021869	ENSOCUP00000004555	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Uncharacterized protein.	0.978
IL1B	LOC100358658	ENSOCUP00000021869	ENSOCUP00000026479	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.992
IL1B	MEFV	ENSOCUP00000021869	ENSOCUP00000004286	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	MEFV innate immuity regulator, pyrin.	0.712