STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (475 aa)    
Predicted Functional Partners:
DKK1
Dickkopf-like protein 1.
    
 0.998
FANCM
FA complementation group M.
   
 0.996
LRP6
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
   
 0.960
DKK2
Dickkopf WNT signaling pathway inhibitor 2.
    
 0.933
CENPT
CENP-T_N domain-containing protein.
   
 0.786
CENPX
Uncharacterized protein.
    
 0.781
CENPW
Uncharacterized protein.
   
 0.780
ASGR1
Asialoglycoprotein receptor 1.
      
 0.708
TMPRSS2
Transmembrane serine protease 2; Belongs to the peptidase S1 family.
    
 
 0.703
DKK3
Dickkopf WNT signaling pathway inhibitor 3.
    
 0.700
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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