STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARRDC4Arrestin domain containing 4. (384 aa)    
Predicted Functional Partners:
NEDD4
NEDD4 E3 ubiquitin protein ligase.
    
 
 0.779
PGPEP1L
Pyroglutamyl-peptidase I like.
   
  
 0.715
WWP2
E3 ubiquitin-protein ligase.
   
 
 0.655
NEDD4L
NEDD4 like E3 ubiquitin protein ligase.
   
 
 0.628
TXN
Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...]
    
 0.581
PLEKHA5
Pleckstrin homology domain containing A5.
    
 
 0.563
ITCH
E3 ubiquitin-protein ligase.
    
 
 0.549
TXNDC2
Thioredoxin domain-containing protein.
   
 0.546
G1TIC3_RABIT
Thioredoxin domain-containing protein.
    
 0.544
TXNDC8
Thioredoxin domain-containing protein.
    
 0.544
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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