HTR1A protein (Oryctolagus cuniculus) - STRING interaction network

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Score

HTR1A

G_PROTEIN_RECEP_F1_2 domain-containing protein. (422 aa)

Predicted Functional Partners:

GNAO1

0.898

GNG4

0.847

ENSOCUP00000035103

0.831

GNB3

0.827

GNAI2

0.823

GNB5

0.814

GHRL

0.784

GNG12

0.783

EDN1

0.778

GNGT1

0.776

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDN1	GHRL	ENSOCUP00000011526	ENSOCUP00000029787	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Uncharacterized protein.	0.436
EDN1	GNB3	ENSOCUP00000011526	ENSOCUP00000011129	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	G protein subunit beta 3.	0.432
EDN1	HTR1A	ENSOCUP00000011526	ENSOCUP00000008436	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.778
ENSOCUP00000035103	GNAI2	ENSOCUP00000035103	ENSOCUP00000019624	G protein gamma domain-containing protein.	G protein subunit alpha i2.	0.978
ENSOCUP00000035103	GNAO1	ENSOCUP00000035103	ENSOCUP00000040227	G protein gamma domain-containing protein.	G protein subunit alpha o1.	0.951
ENSOCUP00000035103	GNB3	ENSOCUP00000035103	ENSOCUP00000011129	G protein gamma domain-containing protein.	G protein subunit beta 3.	0.989
ENSOCUP00000035103	GNB5	ENSOCUP00000035103	ENSOCUP00000010220	G protein gamma domain-containing protein.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.980
ENSOCUP00000035103	GNG12	ENSOCUP00000035103	ENSOCUP00000020657	G protein gamma domain-containing protein.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.773
ENSOCUP00000035103	GNG4	ENSOCUP00000035103	ENSOCUP00000005907	G protein gamma domain-containing protein.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.733
ENSOCUP00000035103	GNGT1	ENSOCUP00000035103	ENSOCUP00000014636	G protein gamma domain-containing protein.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.774
ENSOCUP00000035103	HTR1A	ENSOCUP00000035103	ENSOCUP00000008436	G protein gamma domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.831
GHRL	EDN1	ENSOCUP00000029787	ENSOCUP00000011526	Uncharacterized protein.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.436
GHRL	HTR1A	ENSOCUP00000029787	ENSOCUP00000008436	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.784
GNAI2	ENSOCUP00000035103	ENSOCUP00000019624	ENSOCUP00000035103	G protein subunit alpha i2.	G protein gamma domain-containing protein.	0.978
GNAI2	GNAO1	ENSOCUP00000019624	ENSOCUP00000040227	G protein subunit alpha i2.	G protein subunit alpha o1.	0.982
GNAI2	GNB3	ENSOCUP00000019624	ENSOCUP00000011129	G protein subunit alpha i2.	G protein subunit beta 3.	0.984
GNAI2	GNB5	ENSOCUP00000019624	ENSOCUP00000010220	G protein subunit alpha i2.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.937
GNAI2	GNG12	ENSOCUP00000019624	ENSOCUP00000020657	G protein subunit alpha i2.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.962
GNAI2	GNG4	ENSOCUP00000019624	ENSOCUP00000005907	G protein subunit alpha i2.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.977
GNAI2	GNGT1	ENSOCUP00000019624	ENSOCUP00000014636	G protein subunit alpha i2.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.966