Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
RAC1Rac family small GTPase 1. (199 aa)    
Predicted Functional Partners:
PAK1
Non-specific serine/threonine protein kinase.
   
 0.969
TIAM1
T cell lymphoma invasion and metastasis 1.
    
 0.952
G1TXJ4_RABIT
Uncharacterized protein.
   
 0.940
PAK2
Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...]
   
 0.938
NCF4
P40-phox.
   
 0.936
IQGAP1
IQ motif containing GTPase activating protein 1.
   
 0.936
VAV1
Vav guanine nucleotide exchange factor 1.
   
 0.933
NCF2
Uncharacterized protein.
   
 0.932
CYBB
FAD-binding FR-type domain-containing protein.
   
 0.931
NCKAP1
NCK associated protein 1.
   
 0.918
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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