STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KDM2ALysine demethylase 2A. (1162 aa)    
Predicted Functional Partners:
NEDD8
NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).
    
 0.968
SKP1
Uncharacterized protein; Belongs to the SKP1 family.
   
 0.945
ENSOCUP00000031260
Uncharacterized protein; Belongs to the SKP1 family.
   
 0.945
ENSOCUP00000038972
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
   
 0.945
ENSOCUP00000046782
Skp1_POZ domain-containing protein.
   
 0.945
ENSOCUP00000048996
Uncharacterized protein; Belongs to the SKP1 family.
   
 0.945
CUL1
Cullin 1; Belongs to the cullin family.
    
 0.890
CACUL1
CDK2 associated cullin domain 1.
    
 0.887
CUL3
Cullin 3; Belongs to the cullin family.
    
 0.887
ENSOCUP00000035728
Zf-rbx1 domain-containing protein.
    
 0.880
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.