ITGA3 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ITGA3

Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1072 aa)

Predicted Functional Partners:

ITGB1

0.989

ITGB4

0.949

ITGB5

0.935

ITGB3

0.924

ITGB6

0.901

ITGB2

0.873

ITGB8

0.862

ITGB7

0.858

FN1

0.855

ITGA4

0.840

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FN1	ITGA3	ENSOCUP00000008718	ENSOCUP00000008606	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	0.855
FN1	ITGA4	ENSOCUP00000008718	ENSOCUP00000021994	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.990
FN1	ITGB1	ENSOCUP00000008718	ENSOCUP00000003143	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta; Belongs to the integrin beta chain family.	0.999
FN1	ITGB2	ENSOCUP00000008718	ENSOCUP00000040076	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta.	0.955
FN1	ITGB3	ENSOCUP00000008718	ENSOCUP00000033109	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta; Belongs to the integrin beta chain family.	0.998
FN1	ITGB4	ENSOCUP00000008718	ENSOCUP00000031031	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta.	0.501
FN1	ITGB5	ENSOCUP00000008718	ENSOCUP00000012560	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta; Belongs to the integrin beta chain family.	0.991
FN1	ITGB6	ENSOCUP00000008718	ENSOCUP00000029233	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta; Belongs to the integrin beta chain family.	0.978
FN1	ITGB7	ENSOCUP00000008718	ENSOCUP00000001228	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta; Belongs to the integrin beta chain family.	0.981
FN1	ITGB8	ENSOCUP00000008718	ENSOCUP00000043357	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (By similarity). Required during vasculogenesis (By similarity).	0.926
ITGA3	FN1	ENSOCUP00000008606	ENSOCUP00000008718	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	0.855
ITGA3	ITGA4	ENSOCUP00000008606	ENSOCUP00000021994	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.840
ITGA3	ITGB1	ENSOCUP00000008606	ENSOCUP00000003143	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.989
ITGA3	ITGB2	ENSOCUP00000008606	ENSOCUP00000040076	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin beta.	0.873
ITGA3	ITGB3	ENSOCUP00000008606	ENSOCUP00000033109	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.924
ITGA3	ITGB4	ENSOCUP00000008606	ENSOCUP00000031031	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin beta.	0.949
ITGA3	ITGB5	ENSOCUP00000008606	ENSOCUP00000012560	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.935
ITGA3	ITGB6	ENSOCUP00000008606	ENSOCUP00000029233	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.901
ITGA3	ITGB7	ENSOCUP00000008606	ENSOCUP00000001228	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.858
ITGA3	ITGB8	ENSOCUP00000008606	ENSOCUP00000043357	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (By similarity). Required during vasculogenesis (By similarity).	0.862