STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYP1A2Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (541 aa)    
Predicted Functional Partners:
UGT1
UDP-glucuronosyltransferase 1-4; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds; Belongs to the UDP-glycosyltransferase family.
   
 0.980
LOC100338508
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 0.979
LOC100357038
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 0.979
LOC100351592
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 0.979
CYP7A1
Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]
  
 
 0.978
UGT2C1
UDP-glucuronosyltransferase 2C1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
   
 0.978
UGT2B16
UDP-glucuronosyltransferase 2B16; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Acts on small phenolic agents such as 2-beta-naphthol and 4- methylumbelliferone as well as bulky phenolic compounds like 2- hydroxy- and 4-hydroxybiphenyl. In contrast to 2B13 it is active toward 4-hydroxyesterone; Belongs to the UDP-glycosyltransferase family.
   
 0.974
UGT2B14
UDP-glucuronosyltransferase 2B14; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds; Belongs to the UDP-glycosyltransferase family.
   
 0.973
LOC100340513
Uncharacterized protein.
   
 0.973
G1TXJ5_RABIT
Uncharacterized protein.
   
 0.971
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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