PLEKHG6 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

PLEKHG6

Pleckstrin homology and RhoGEF domain containing G6. (782 aa)

Predicted Functional Partners:

TRADD

0.810

TNFSF15

0.793

RIPK1

0.744

TRAF1

0.720

TNF

0.719

RHOG

0.714

RND3

0.705

LTA

0.694

IKBKB

0.646

CYLD

0.646

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYLD	IKBKB	ENSOCUP00000032691	ENSOCUP00000006175	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.892
CYLD	PLEKHG6	ENSOCUP00000032691	ENSOCUP00000008732	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Pleckstrin homology and RhoGEF domain containing G6.	0.646
CYLD	RIPK1	ENSOCUP00000032691	ENSOCUP00000010138	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Receptor interacting serine/threonine kinase 1.	0.989
CYLD	TRADD	ENSOCUP00000032691	ENSOCUP00000018718	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	TNFRSF1A associated via death domain.	0.887
CYLD	TRAF1	ENSOCUP00000032691	ENSOCUP00000004916	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	TNF receptor-associated factor.	0.970
IKBKB	CYLD	ENSOCUP00000006175	ENSOCUP00000032691	Inhibitor of nuclear factor kappa B kinase subunit beta.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.892
IKBKB	PLEKHG6	ENSOCUP00000006175	ENSOCUP00000008732	Inhibitor of nuclear factor kappa B kinase subunit beta.	Pleckstrin homology and RhoGEF domain containing G6.	0.646
IKBKB	RIPK1	ENSOCUP00000006175	ENSOCUP00000010138	Inhibitor of nuclear factor kappa B kinase subunit beta.	Receptor interacting serine/threonine kinase 1.	0.990
IKBKB	TRADD	ENSOCUP00000006175	ENSOCUP00000018718	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNFRSF1A associated via death domain.	0.909
IKBKB	TRAF1	ENSOCUP00000006175	ENSOCUP00000004916	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNF receptor-associated factor.	0.975
LTA	PLEKHG6	ENSOCUP00000005782	ENSOCUP00000008732	Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.	Pleckstrin homology and RhoGEF domain containing G6.	0.694
LTA	TNF	ENSOCUP00000005782	ENSOCUP00000005787	Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.847
LTA	TNFSF15	ENSOCUP00000005782	ENSOCUP00000010059	Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.	TNF superfamily member 15.	0.460
LTA	TRAF1	ENSOCUP00000005782	ENSOCUP00000004916	Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.	TNF receptor-associated factor.	0.612
PLEKHG6	CYLD	ENSOCUP00000008732	ENSOCUP00000032691	Pleckstrin homology and RhoGEF domain containing G6.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.646
PLEKHG6	IKBKB	ENSOCUP00000008732	ENSOCUP00000006175	Pleckstrin homology and RhoGEF domain containing G6.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.646
PLEKHG6	LTA	ENSOCUP00000008732	ENSOCUP00000005782	Pleckstrin homology and RhoGEF domain containing G6.	Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.	0.694
PLEKHG6	RHOG	ENSOCUP00000008732	ENSOCUP00000015118	Pleckstrin homology and RhoGEF domain containing G6.	Ras homolog family member G.	0.714
PLEKHG6	RIPK1	ENSOCUP00000008732	ENSOCUP00000010138	Pleckstrin homology and RhoGEF domain containing G6.	Receptor interacting serine/threonine kinase 1.	0.744
PLEKHG6	RND3	ENSOCUP00000008732	ENSOCUP00000001502	Pleckstrin homology and RhoGEF domain containing G6.	Rho family GTPase 3.	0.705