STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHRNECholinergic receptor nicotinic epsilon subunit. (491 aa)    
Predicted Functional Partners:
CHRNA1
Cholinergic receptor nicotinic alpha 1 subunit.
  
0.851
RAPSN
Receptor associated protein of the synapse.
   
 
 0.834
COLQ
Collagen like tail subunit of asymmetric acetylcholinesterase.
    
 
 0.754
MUSK
Receptor protein-tyrosine kinase.
   
 
 0.742
CHRNA5
Cholinergic receptor nicotinic alpha 5 subunit.
  
0.646
CHRNB3
Cholinergic receptor nicotinic beta 3 subunit.
  
0.620
CHRNA4
Cholinergic receptor nicotinic alpha 4 subunit.
  
0.611
CHRNA2
Cholinergic receptor nicotinic alpha 2 subunit.
  
0.609
HACD1
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...]
   
  
 0.602
SCN4A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
   
  
 0.582
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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