Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
HNRNPLLHeterogeneous nuclear ribonucleoprotein L like. (541 aa)    
Predicted Functional Partners:
HNRNPK
Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]
   
 0.879
PTBP3
Polypyrimidine tract binding protein 3.
   
 0.875
QKI
QKI, KH domain containing RNA binding.
   
 
 0.858
HNRNPU
Heterogeneous nuclear ribonucleoprotein U.
   
 0.857
HNRNPD
Heterogeneous nuclear ribonucleoprotein D.
   
 0.851
HNRNPDL
Heterogeneous nuclear ribonucleoprotein D like.
   
 0.848
PTBP2
Polypyrimidine tract binding protein 2.
   
0.833
HNRNPA2B1-2
Heterogeneous nuclear ribonucleoprotein A2/B1.
   
 0.832
HNRNPA2B1
Heterogeneous nuclear ribonucleoprotein A2/B1.
   
 0.829
HNRNPR
Heterogeneous nuclear ribonucleoprotein R.
   
 0.817
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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