Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DISC1DISC1 scaffold protein. (859 aa)    
Predicted Functional Partners:
FEZ1
Fasciculation and elongation protein zeta 1.
    
 
 0.835
NDEL1
Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...]
    
 
 0.820
PDE4B
Phosphodiesterase.
    
 
 0.762
KALRN
Kalirin RhoGEF kinase.
    
 
 0.725
NRG1
Neuregulin 1.
    
 
 0.710
DIXDC1
DIX domain containing 1.
      
 0.685
PDE4A
Phosphodiesterase.
    
 
 0.645
NDE1
NudE neurodevelopment protein 1.
    
 
 0.638
CEP63
Centrosomal protein 63.
    
 
 0.635
ZNF804A
Zinc finger protein 804A.
      
 0.625
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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