HNRNPK protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

HNRNPK

Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (463 aa)

Predicted Functional Partners:

HNRNPU

0.991

HNRNPL

0.979

PCBP1

0.969

HNRNPD

0.968

HNRNPA2B1

0.959

HNRNPA2B1-2

0.958

HNRNPR

0.948

HNRNPA1

0.938

HNRNPA3

0.915

DDX5

0.914

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX5	HNRNPA1	ENSOCUP00000043262	ENSOCUP00000011492	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.845
DDX5	HNRNPA2B1	ENSOCUP00000043262	ENSOCUP00000021456	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Heterogeneous nuclear ribonucleoprotein A2/B1.	0.857
DDX5	HNRNPA2B1-2	ENSOCUP00000043262	ENSOCUP00000037182	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Heterogeneous nuclear ribonucleoprotein A2/B1.	0.857
DDX5	HNRNPA3	ENSOCUP00000043262	ENSOCUP00000002378	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.762
DDX5	HNRNPD	ENSOCUP00000043262	ENSOCUP00000001170	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Heterogeneous nuclear ribonucleoprotein D.	0.665
DDX5	HNRNPK	ENSOCUP00000043262	ENSOCUP00000008932	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	0.914
DDX5	HNRNPL	ENSOCUP00000043262	ENSOCUP00000023948	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	0.775
DDX5	HNRNPR	ENSOCUP00000043262	ENSOCUP00000005778	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Heterogeneous nuclear ribonucleoprotein R.	0.927
DDX5	HNRNPU	ENSOCUP00000043262	ENSOCUP00000044849	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Heterogeneous nuclear ribonucleoprotein U.	0.927
DDX5	PCBP1	ENSOCUP00000043262	ENSOCUP00000020092	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Poly(rC)-binding protein 1; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.	0.721
HNRNPA1	DDX5	ENSOCUP00000011492	ENSOCUP00000043262	Uncharacterized protein.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.845
HNRNPA1	HNRNPA2B1	ENSOCUP00000011492	ENSOCUP00000021456	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein A2/B1.	0.663
HNRNPA1	HNRNPA2B1-2	ENSOCUP00000011492	ENSOCUP00000037182	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein A2/B1.	0.663
HNRNPA1	HNRNPA3	ENSOCUP00000011492	ENSOCUP00000002378	Uncharacterized protein.	Uncharacterized protein.	0.565
HNRNPA1	HNRNPD	ENSOCUP00000011492	ENSOCUP00000001170	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein D.	0.753
HNRNPA1	HNRNPK	ENSOCUP00000011492	ENSOCUP00000008932	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...]	0.938
HNRNPA1	HNRNPL	ENSOCUP00000011492	ENSOCUP00000023948	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.	0.921
HNRNPA1	HNRNPR	ENSOCUP00000011492	ENSOCUP00000005778	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein R.	0.787
HNRNPA1	HNRNPU	ENSOCUP00000011492	ENSOCUP00000044849	Uncharacterized protein.	Heterogeneous nuclear ribonucleoprotein U.	0.935
HNRNPA1	PCBP1	ENSOCUP00000011492	ENSOCUP00000020092	Uncharacterized protein.	Poly(rC)-binding protein 1; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.	0.883

page 1 of 6

Server load: low (22%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About