PDE6D protein (Oryctolagus cuniculus) - STRING interaction network

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PDE6D

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] (150 aa)

Predicted Functional Partners:

ARL3

0.932

ARL13B

0.923

ENSOCUP00000039195

0.921

GUCY1B1

0.894

RAB28

0.847

ADCY3

0.809

G1TW84_RABIT

0.809

GUCY1A1

0.782

GUCY1A2

0.782

RPGRIP1

0.776

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY3	ARL13B	ENSOCUP00000013273	ENSOCUP00000026791	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	ADP ribosylation factor like GTPase 13B.	0.613
ADCY3	PDE6D	ENSOCUP00000013273	ENSOCUP00000008961	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]	0.809
ARL13B	ADCY3	ENSOCUP00000026791	ENSOCUP00000013273	ADP ribosylation factor like GTPase 13B.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.613
ARL13B	ARL3	ENSOCUP00000026791	ENSOCUP00000005021	ADP ribosylation factor like GTPase 13B.	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	0.665
ARL13B	PDE6D	ENSOCUP00000026791	ENSOCUP00000008961	ADP ribosylation factor like GTPase 13B.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]	0.923
ARL13B	RAB28	ENSOCUP00000026791	ENSOCUP00000030835	ADP ribosylation factor like GTPase 13B.	RAB28, member RAS oncogene family.	0.424
ARL3	ARL13B	ENSOCUP00000005021	ENSOCUP00000026791	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	ADP ribosylation factor like GTPase 13B.	0.665
ARL3	ENSOCUP00000039195	ENSOCUP00000005021	ENSOCUP00000039195	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein.	0.464
ARL3	G1TW84_RABIT	ENSOCUP00000005021	ENSOCUP00000021328	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein.	0.465
ARL3	PDE6D	ENSOCUP00000005021	ENSOCUP00000008961	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]	0.932
ARL3	RAB28	ENSOCUP00000005021	ENSOCUP00000030835	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	RAB28, member RAS oncogene family.	0.559
ENSOCUP00000039195	ARL3	ENSOCUP00000039195	ENSOCUP00000005021	Uncharacterized protein.	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	0.464
ENSOCUP00000039195	PDE6D	ENSOCUP00000039195	ENSOCUP00000008961	Uncharacterized protein.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]	0.921
G1TW84_RABIT	ARL3	ENSOCUP00000021328	ENSOCUP00000005021	Uncharacterized protein.	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	0.465
G1TW84_RABIT	PDE6D	ENSOCUP00000021328	ENSOCUP00000008961	Uncharacterized protein.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]	0.809
G1TW84_RABIT	RPGRIP1	ENSOCUP00000021328	ENSOCUP00000009288	Uncharacterized protein.	RPGR interacting protein 1.	0.910
GUCY1A1	GUCY1A2	ENSOCUP00000003847	ENSOCUP00000003877	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.938
GUCY1A1	GUCY1B1	ENSOCUP00000003847	ENSOCUP00000028008	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.999
GUCY1A1	PDE6D	ENSOCUP00000003847	ENSOCUP00000008961	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]	0.782
GUCY1A2	GUCY1A1	ENSOCUP00000003877	ENSOCUP00000003847	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.938

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