Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADAM17ADAM metallopeptidase domain 17. (827 aa)    
Predicted Functional Partners:
RHBDF2
Rhomboid 5 homolog 2.
    
 0.977
RHBDF1
Rhomboid 5 homolog 1.
    
 0.973
HBEGF
Heparin binding EGF like growth factor.
    
 0.965
NOTCH3
Notch receptor 3.
    
 0.947
NOTCH2
Notch receptor 2.
    
 0.947
NOTCH4
Uncharacterized protein.
    
 0.941
IL6R
Interleukin 6 receptor.
   
 
 0.936
TIMP3
Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity).
    
 
 0.922
TGFA
Transforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar (By similarity). Inhibitor of acid secretion. Inhibitor of aminopyrine uptake in parietal cells (in vitro).
   
 
 0.919
MERTK
MER proto-oncogene, tyrosine kinase.
    
 0.918
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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