node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARAF | RAF1 | ENSOCUP00000014138 | ENSOCUP00000036596 | A-Raf proto-oncogene, serine/threonine kinase. | Raf-1 proto-oncogene, serine/threonine kinase. | 0.903 |
ARAF | YWHAB | ENSOCUP00000014138 | ENSOCUP00000034985 | A-Raf proto-oncogene, serine/threonine kinase. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. | 0.989 |
ARAF | YWHAQ | ENSOCUP00000014138 | ENSOCUP00000009032 | A-Raf proto-oncogene, serine/threonine kinase. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.976 |
ARAF | YWHAZ | ENSOCUP00000014138 | ENSOCUP00000000636 | A-Raf proto-oncogene, serine/threonine kinase. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. | 0.991 |
CDC25C | YWHAB | ENSOCUP00000007258 | ENSOCUP00000034985 | Cell division cycle 25C. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. | 0.964 |
CDC25C | YWHAQ | ENSOCUP00000007258 | ENSOCUP00000009032 | Cell division cycle 25C. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.965 |
CDC25C | YWHAZ | ENSOCUP00000007258 | ENSOCUP00000000636 | Cell division cycle 25C. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. | 0.977 |
CTNNA1 | CTNNA2 | ENSOCUP00000006694 | ENSOCUP00000031755 | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | Catenin alpha 2. | 0.902 |
CTNNA1 | YWHAB | ENSOCUP00000006694 | ENSOCUP00000034985 | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. | 0.922 |
CTNNA1 | YWHAQ | ENSOCUP00000006694 | ENSOCUP00000009032 | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.930 |
CTNNA1 | YWHAZ | ENSOCUP00000006694 | ENSOCUP00000000636 | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. | 0.923 |
CTNNA2 | CTNNA1 | ENSOCUP00000031755 | ENSOCUP00000006694 | Catenin alpha 2. | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] | 0.902 |
CTNNA2 | YWHAB | ENSOCUP00000031755 | ENSOCUP00000034985 | Catenin alpha 2. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. | 0.921 |
CTNNA2 | YWHAQ | ENSOCUP00000031755 | ENSOCUP00000009032 | Catenin alpha 2. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.930 |
CTNNA2 | YWHAZ | ENSOCUP00000031755 | ENSOCUP00000000636 | Catenin alpha 2. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. | 0.927 |
FOXO3 | YWHAB | ENSOCUP00000009021 | ENSOCUP00000034985 | Fork-head domain-containing protein. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. | 0.963 |
FOXO3 | YWHAQ | ENSOCUP00000009021 | ENSOCUP00000009032 | Fork-head domain-containing protein. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.969 |
FOXO3 | YWHAZ | ENSOCUP00000009021 | ENSOCUP00000000636 | Fork-head domain-containing protein. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. | 0.974 |
RAF1 | ARAF | ENSOCUP00000036596 | ENSOCUP00000014138 | Raf-1 proto-oncogene, serine/threonine kinase. | A-Raf proto-oncogene, serine/threonine kinase. | 0.903 |
RAF1 | YWHAB | ENSOCUP00000036596 | ENSOCUP00000034985 | Raf-1 proto-oncogene, serine/threonine kinase. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. | 0.978 |