SLC51B protein (Oryctolagus cuniculus) - STRING interaction network

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Score

SLC51B

Solute carrier family 51 beta subunit. (130 aa)

Predicted Functional Partners:

SLC51A

0.804

SLC10A2

0.793

ABCB11

0.751

CYP7A1

0.700

NR1H4

0.671

ABCC3

0.663

FABP6

0.636

ABCC4

0.626

ABCC2

0.616

SLCO1B3

0.609

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB11	ABCC2	ENSOCUP00000001184	ENSOCUP00000007069	Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts.	Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity).	0.601
ABCB11	ABCC3	ENSOCUP00000001184	ENSOCUP00000002392	Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts.	ATP binding cassette subfamily C member 3.	0.562
ABCB11	ABCC4	ENSOCUP00000001184	ENSOCUP00000012575	Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts.	ATP binding cassette subfamily C member 4.	0.543
ABCB11	CYP7A1	ENSOCUP00000001184	ENSOCUP00000010572	Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts.	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	0.889
ABCB11	FABP6	ENSOCUP00000001184	ENSOCUP00000004716	Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts.	Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. Stimulates gastric acid and pepsinogen secretion (By similarity). Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.648
ABCB11	NR1H4	ENSOCUP00000001184	ENSOCUP00000006201	Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts.	Uncharacterized protein.	0.898
ABCB11	SLC10A2	ENSOCUP00000001184	ENSOCUP00000004722	Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts.	Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity).	0.862
ABCB11	SLC51B	ENSOCUP00000001184	ENSOCUP00000009231	Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts.	Solute carrier family 51 beta subunit.	0.751
ABCB11	SLCO1B3	ENSOCUP00000001184	ENSOCUP00000013154	Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts.	Solute carrier organic anion transporter family member.	0.748
ABCC2	ABCB11	ENSOCUP00000007069	ENSOCUP00000001184	Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity).	Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts.	0.601
ABCC2	CYP7A1	ENSOCUP00000007069	ENSOCUP00000010572	Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity).	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	0.679
ABCC2	NR1H4	ENSOCUP00000007069	ENSOCUP00000006201	Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity).	Uncharacterized protein.	0.715
ABCC2	SLC10A2	ENSOCUP00000007069	ENSOCUP00000004722	Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity).	Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity).	0.674
ABCC2	SLC51B	ENSOCUP00000007069	ENSOCUP00000009231	Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity).	Solute carrier family 51 beta subunit.	0.616
ABCC2	SLCO1B3	ENSOCUP00000007069	ENSOCUP00000013154	Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity).	Solute carrier organic anion transporter family member.	0.644
ABCC3	ABCB11	ENSOCUP00000002392	ENSOCUP00000001184	ATP binding cassette subfamily C member 3.	Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts.	0.562
ABCC3	CYP7A1	ENSOCUP00000002392	ENSOCUP00000010572	ATP binding cassette subfamily C member 3.	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	0.581
ABCC3	NR1H4	ENSOCUP00000002392	ENSOCUP00000006201	ATP binding cassette subfamily C member 3.	Uncharacterized protein.	0.481
ABCC3	SLC10A2	ENSOCUP00000002392	ENSOCUP00000004722	ATP binding cassette subfamily C member 3.	Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity).	0.488
ABCC3	SLC51B	ENSOCUP00000002392	ENSOCUP00000009231	ATP binding cassette subfamily C member 3.	Solute carrier family 51 beta subunit.	0.663