| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCB11 | ABCC2 | ENSOCUP00000001184 | ENSOCUP00000007069 | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity). | 0.531 |
| ABCB11 | ABCC3 | ENSOCUP00000001184 | ENSOCUP00000002392 | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | ATP binding cassette subfamily C member 3. | 0.456 |
| ABCB11 | CYP7A1 | ENSOCUP00000001184 | ENSOCUP00000010572 | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...] | 0.905 |
| ABCB11 | FABP6 | ENSOCUP00000001184 | ENSOCUP00000004716 | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. Stimulates gastric acid and pepsinogen secretion (By similarity). Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.682 |
| ABCB11 | NR1H4 | ENSOCUP00000001184 | ENSOCUP00000006201 | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | Uncharacterized protein. | 0.917 |
| ABCB11 | SLC10A2 | ENSOCUP00000001184 | ENSOCUP00000004722 | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity). | 0.831 |
| ABCB11 | SLC51B | ENSOCUP00000001184 | ENSOCUP00000009231 | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | Solute carrier family 51 beta subunit. | 0.750 |
| ABCB11 | SLCO1B3 | ENSOCUP00000001184 | ENSOCUP00000013154 | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | Solute carrier organic anion transporter family member. | 0.734 |
| ABCC2 | ABCB11 | ENSOCUP00000007069 | ENSOCUP00000001184 | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity). | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | 0.531 |
| ABCC2 | CYP7A1 | ENSOCUP00000007069 | ENSOCUP00000010572 | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity). | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...] | 0.727 |
| ABCC2 | NR1H4 | ENSOCUP00000007069 | ENSOCUP00000006201 | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity). | Uncharacterized protein. | 0.781 |
| ABCC2 | SLC10A2 | ENSOCUP00000007069 | ENSOCUP00000004722 | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity). | Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity). | 0.687 |
| ABCC2 | SLC51B | ENSOCUP00000007069 | ENSOCUP00000009231 | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity). | Solute carrier family 51 beta subunit. | 0.650 |
| ABCC2 | SLCO1B3 | ENSOCUP00000007069 | ENSOCUP00000013154 | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter (By similarity). | Solute carrier organic anion transporter family member. | 0.658 |
| ABCC3 | ABCB11 | ENSOCUP00000002392 | ENSOCUP00000001184 | ATP binding cassette subfamily C member 3. | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | 0.456 |
| ABCC3 | CYP7A1 | ENSOCUP00000002392 | ENSOCUP00000010572 | ATP binding cassette subfamily C member 3. | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...] | 0.607 |
| ABCC3 | NR1H4 | ENSOCUP00000002392 | ENSOCUP00000006201 | ATP binding cassette subfamily C member 3. | Uncharacterized protein. | 0.547 |
| ABCC3 | SLC10A2 | ENSOCUP00000002392 | ENSOCUP00000004722 | ATP binding cassette subfamily C member 3. | Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity). | 0.550 |
| ABCC3 | SLC51B | ENSOCUP00000002392 | ENSOCUP00000009231 | ATP binding cassette subfamily C member 3. | Solute carrier family 51 beta subunit. | 0.676 |
| CYP7A1 | ABCB11 | ENSOCUP00000010572 | ENSOCUP00000001184 | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...] | Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. | 0.905 |
