PITRM1 protein (Oryctolagus cuniculus) - STRING interaction network

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PITRM1

Pitrilysin metallopeptidase 1. (1037 aa)

Predicted Functional Partners:

APP

0.788

PDHB

0.740

SUCLG2

0.738

COQ2

0.716

HSPD1

0.709

ZC2HC1A

0.703

MIPEP

0.682

XPNPEP2

0.674

XPNPEP1

0.674

PDHA2

0.633

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	PITRM1	ENSOCUP00000009130	ENSOCUP00000009510	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Pitrilysin metallopeptidase 1.	0.788
APP	XPNPEP2	ENSOCUP00000009130	ENSOCUP00000022176	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family.	0.484
COQ2	HSPD1	ENSOCUP00000009571	ENSOCUP00000010958	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	0.489
COQ2	PITRM1	ENSOCUP00000009571	ENSOCUP00000009510	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	Pitrilysin metallopeptidase 1.	0.716
HSPD1	COQ2	ENSOCUP00000010958	ENSOCUP00000009571	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.489
HSPD1	PDHA2	ENSOCUP00000010958	ENSOCUP00000002193	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.649
HSPD1	PDHB	ENSOCUP00000010958	ENSOCUP00000013424	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.864
HSPD1	PITRM1	ENSOCUP00000010958	ENSOCUP00000009510	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	Pitrilysin metallopeptidase 1.	0.709
HSPD1	SUCLG2	ENSOCUP00000010958	ENSOCUP00000040644	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.482
MIPEP	PITRM1	ENSOCUP00000038989	ENSOCUP00000009510	Mitochondrial intermediate peptidase.	Pitrilysin metallopeptidase 1.	0.682
PDHA2	HSPD1	ENSOCUP00000002193	ENSOCUP00000010958	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	0.649
PDHA2	PDHB	ENSOCUP00000002193	ENSOCUP00000013424	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.999
PDHA2	PITRM1	ENSOCUP00000002193	ENSOCUP00000009510	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Pitrilysin metallopeptidase 1.	0.633
PDHA2	SUCLG2	ENSOCUP00000002193	ENSOCUP00000040644	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.472
PDHB	HSPD1	ENSOCUP00000013424	ENSOCUP00000010958	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	0.864
PDHB	PDHA2	ENSOCUP00000013424	ENSOCUP00000002193	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
PDHB	PITRM1	ENSOCUP00000013424	ENSOCUP00000009510	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Pitrilysin metallopeptidase 1.	0.740
PDHB	SUCLG2	ENSOCUP00000013424	ENSOCUP00000040644	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.742
PITRM1	APP	ENSOCUP00000009510	ENSOCUP00000009130	Pitrilysin metallopeptidase 1.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.788
PITRM1	COQ2	ENSOCUP00000009510	ENSOCUP00000009571	Pitrilysin metallopeptidase 1.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.716