node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | BGLAP | ENSOCUP00000014006 | ENSOCUP00000020318 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.650 |
ALB | COL1A1 | ENSOCUP00000014006 | ENSOCUP00000011096 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Collagen alpha-1(I) chain. | 0.678 |
ALB | COL1A2 | ENSOCUP00000014006 | ENSOCUP00000010575 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | 0.454 |
ALB | COL3A1 | ENSOCUP00000014006 | ENSOCUP00000012893 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Collagen type III alpha 1 chain. | 0.448 |
ALB | DCN | ENSOCUP00000014006 | ENSOCUP00000006027 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.551 |
ALB | LUM | ENSOCUP00000014006 | ENSOCUP00000004852 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Lumican. | 0.470 |
ALB | RUNX2 | ENSOCUP00000014006 | ENSOCUP00000010093 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | RUNX family transcription factor 2. | 0.679 |
ALB | SPARC | ENSOCUP00000014006 | ENSOCUP00000010426 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. | 0.972 |
ALB | SPP1 | ENSOCUP00000014006 | ENSOCUP00000021885 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.753 |
BGLAP | ALB | ENSOCUP00000020318 | ENSOCUP00000014006 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | 0.650 |
BGLAP | COL1A1 | ENSOCUP00000020318 | ENSOCUP00000011096 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Collagen alpha-1(I) chain. | 0.776 |
BGLAP | COL1A2 | ENSOCUP00000020318 | ENSOCUP00000010575 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | 0.608 |
BGLAP | DCN | ENSOCUP00000020318 | ENSOCUP00000006027 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.731 |
BGLAP | RUNX2 | ENSOCUP00000020318 | ENSOCUP00000010093 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | RUNX family transcription factor 2. | 0.944 |
BGLAP | SPARC | ENSOCUP00000020318 | ENSOCUP00000010426 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. | 0.959 |
BGLAP | SPP1 | ENSOCUP00000020318 | ENSOCUP00000021885 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.974 |
COL1A1 | ALB | ENSOCUP00000011096 | ENSOCUP00000014006 | Collagen alpha-1(I) chain. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | 0.678 |
COL1A1 | BGLAP | ENSOCUP00000011096 | ENSOCUP00000020318 | Collagen alpha-1(I) chain. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.776 |
COL1A1 | COL1A2 | ENSOCUP00000011096 | ENSOCUP00000010575 | Collagen alpha-1(I) chain. | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | 0.989 |
COL1A1 | COL3A1 | ENSOCUP00000011096 | ENSOCUP00000012893 | Collagen alpha-1(I) chain. | Collagen type III alpha 1 chain. | 0.965 |