STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRAP2GRB2 related adaptor protein 2. (267 aa)    
Predicted Functional Partners:
LCP2
Lymphocyte cytosolic protein 2.
   
 0.999
ITSN2
Intersectin 2.
     
0.944
LAT
Linker for activation of T cells.
   
 0.921
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
   
 0.902
ZAP70
Tyrosine-protein kinase.
   
 0.891
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
   
 0.884
SHC1
SHC adaptor protein 1.
   
 0.880
VAV1
Vav guanine nucleotide exchange factor 1.
    
 0.880
PTPN23
Protein tyrosine phosphatase non-receptor type 23.
   
 0.874
ITK
Tyrosine-protein kinase.
   
 0.857
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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