AGTR2 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

AGTR2

Angiotensin receptor 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)

Predicted Functional Partners:

AGT

0.999

AGTR1

0.976

GNAQ

0.917

EDN1

0.833

ACE2

0.827

ACE

0.805

EDN3

0.804

EDN2

0.759

LOC103351595

0.753

REN

0.705

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ACE2	ENSOCUP00000022251	ENSOCUP00000015275	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Angiotensin-converting enzyme.	0.523
ACE	AGT	ENSOCUP00000022251	ENSOCUP00000000417	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Angiotensinogen; Belongs to the serpin family.	0.979
ACE	AGTR1	ENSOCUP00000022251	ENSOCUP00000028622	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family.	0.929
ACE	AGTR2	ENSOCUP00000022251	ENSOCUP00000010638	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Angiotensin receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.805
ACE	EDN1	ENSOCUP00000022251	ENSOCUP00000011526	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.773
ACE	REN	ENSOCUP00000022251	ENSOCUP00000017597	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	Renin; Belongs to the peptidase A1 family.	0.981
ACE2	ACE	ENSOCUP00000015275	ENSOCUP00000022251	Angiotensin-converting enzyme.	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	0.523
ACE2	AGT	ENSOCUP00000015275	ENSOCUP00000000417	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.985
ACE2	AGTR1	ENSOCUP00000015275	ENSOCUP00000028622	Angiotensin-converting enzyme.	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family.	0.967
ACE2	AGTR2	ENSOCUP00000015275	ENSOCUP00000010638	Angiotensin-converting enzyme.	Angiotensin receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.827
ACE2	EDN1	ENSOCUP00000015275	ENSOCUP00000011526	Angiotensin-converting enzyme.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.765
ACE2	LOC103351595	ENSOCUP00000015275	ENSOCUP00000037472	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.490
ACE2	REN	ENSOCUP00000015275	ENSOCUP00000017597	Angiotensin-converting enzyme.	Renin; Belongs to the peptidase A1 family.	0.981
AGT	ACE	ENSOCUP00000000417	ENSOCUP00000022251	Angiotensinogen; Belongs to the serpin family.	Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.	0.979
AGT	ACE2	ENSOCUP00000000417	ENSOCUP00000015275	Angiotensinogen; Belongs to the serpin family.	Angiotensin-converting enzyme.	0.985
AGT	AGTR1	ENSOCUP00000000417	ENSOCUP00000028622	Angiotensinogen; Belongs to the serpin family.	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family.	0.999
AGT	AGTR2	ENSOCUP00000000417	ENSOCUP00000010638	Angiotensinogen; Belongs to the serpin family.	Angiotensin receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.999
AGT	EDN1	ENSOCUP00000000417	ENSOCUP00000011526	Angiotensinogen; Belongs to the serpin family.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.808
AGT	EDN2	ENSOCUP00000000417	ENSOCUP00000001041	Angiotensinogen; Belongs to the serpin family.	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.417
AGT	EDN3	ENSOCUP00000000417	ENSOCUP00000046269	Angiotensinogen; Belongs to the serpin family.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.492