RHOU protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF6	ITSN2	ENSOCUP00000034207	ENSOCUP00000019448	Rac/Cdc42 guanine nucleotide exchange factor 6.	Intersectin 2.	0.692
ARHGEF6	LOC100346323	ENSOCUP00000034207	ENSOCUP00000015500	Rac/Cdc42 guanine nucleotide exchange factor 6.	Uncharacterized protein.	0.543
ARHGEF6	NCK1	ENSOCUP00000034207	ENSOCUP00000006673	Rac/Cdc42 guanine nucleotide exchange factor 6.	Cytoplasmic protein.	0.805
ARHGEF6	NCK2	ENSOCUP00000034207	ENSOCUP00000023883	Rac/Cdc42 guanine nucleotide exchange factor 6.	Cytoplasmic protein.	0.888
ARHGEF6	PAK1	ENSOCUP00000034207	ENSOCUP00000036636	Rac/Cdc42 guanine nucleotide exchange factor 6.	Non-specific serine/threonine protein kinase.	0.975
ARHGEF6	PAK2	ENSOCUP00000034207	ENSOCUP00000007111	Rac/Cdc42 guanine nucleotide exchange factor 6.	Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...]	0.978
ARHGEF6	PAK3	ENSOCUP00000034207	ENSOCUP00000049029	Rac/Cdc42 guanine nucleotide exchange factor 6.	Non-specific serine/threonine protein kinase.	0.974
ARHGEF6	PARD6A	ENSOCUP00000034207	ENSOCUP00000007788	Rac/Cdc42 guanine nucleotide exchange factor 6.	Par-6 family cell polarity regulator alpha.	0.450
ARHGEF6	PARD6B	ENSOCUP00000034207	ENSOCUP00000013738	Rac/Cdc42 guanine nucleotide exchange factor 6.	Par-6 family cell polarity regulator beta.	0.450
ARHGEF6	RHOU	ENSOCUP00000034207	ENSOCUP00000010835	Rac/Cdc42 guanine nucleotide exchange factor 6.	Ras homolog family member U.	0.749
ITSN2	ARHGEF6	ENSOCUP00000019448	ENSOCUP00000034207	Intersectin 2.	Rac/Cdc42 guanine nucleotide exchange factor 6.	0.692
ITSN2	LOC100346323	ENSOCUP00000019448	ENSOCUP00000015500	Intersectin 2.	Uncharacterized protein.	0.791
ITSN2	PAK1	ENSOCUP00000019448	ENSOCUP00000036636	Intersectin 2.	Non-specific serine/threonine protein kinase.	0.548
ITSN2	PAK2	ENSOCUP00000019448	ENSOCUP00000007111	Intersectin 2.	Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...]	0.495
ITSN2	PAK3	ENSOCUP00000019448	ENSOCUP00000049029	Intersectin 2.	Non-specific serine/threonine protein kinase.	0.471
ITSN2	RHOU	ENSOCUP00000019448	ENSOCUP00000010835	Intersectin 2.	Ras homolog family member U.	0.835
LOC100346323	ARHGEF6	ENSOCUP00000015500	ENSOCUP00000034207	Uncharacterized protein.	Rac/Cdc42 guanine nucleotide exchange factor 6.	0.543
LOC100346323	ITSN2	ENSOCUP00000015500	ENSOCUP00000019448	Uncharacterized protein.	Intersectin 2.	0.791
LOC100346323	PAK1	ENSOCUP00000015500	ENSOCUP00000036636	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.415
LOC100346323	PAK2	ENSOCUP00000015500	ENSOCUP00000007111	Uncharacterized protein.	Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...]	0.415