| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C3 | C5 | ENSOCUP00000006634 | ENSOCUP00000004927 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | Complement C5. | 0.674 |
| C3 | C6 | ENSOCUP00000006634 | ENSOCUP00000048038 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | Complement C6. | 0.760 |
| C3 | C8A | ENSOCUP00000006634 | ENSOCUP00000032867 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | 0.484 |
| C3 | C9 | ENSOCUP00000006634 | ENSOCUP00000010939 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. | 0.826 |
| C3 | CD59 | ENSOCUP00000006634 | ENSOCUP00000036438 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. | 0.492 |
| C3 | CLU | ENSOCUP00000006634 | ENSOCUP00000005178 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] | 0.670 |
| C3 | ENSOCUP00000027220 | ENSOCUP00000006634 | ENSOCUP00000027220 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | Anaphylatoxin-like domain-containing protein. | 0.622 |
| C3 | G1TPZ5_RABIT | ENSOCUP00000006634 | ENSOCUP00000019085 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | Uncharacterized protein. | 0.818 |
| C5 | C3 | ENSOCUP00000004927 | ENSOCUP00000006634 | Complement C5. | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | 0.674 |
| C5 | C6 | ENSOCUP00000004927 | ENSOCUP00000048038 | Complement C5. | Complement C6. | 0.992 |
| C5 | C8A | ENSOCUP00000004927 | ENSOCUP00000032867 | Complement C5. | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | 0.929 |
| C5 | C8B | ENSOCUP00000004927 | ENSOCUP00000042473 | Complement C5. | Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. | 0.894 |
| C5 | C9 | ENSOCUP00000004927 | ENSOCUP00000010939 | Complement C5. | Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. | 0.991 |
| C5 | CD59 | ENSOCUP00000004927 | ENSOCUP00000036438 | Complement C5. | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. | 0.743 |
| C5 | CLU | ENSOCUP00000004927 | ENSOCUP00000005178 | Complement C5. | Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] | 0.446 |
| C5 | G1TPZ5_RABIT | ENSOCUP00000004927 | ENSOCUP00000019085 | Complement C5. | Uncharacterized protein. | 0.600 |
| C5 | LOC100346672 | ENSOCUP00000004927 | ENSOCUP00000008700 | Complement C5. | Uncharacterized protein. | 0.674 |
| C6 | C3 | ENSOCUP00000048038 | ENSOCUP00000006634 | Complement C6. | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | 0.760 |
| C6 | C5 | ENSOCUP00000048038 | ENSOCUP00000004927 | Complement C6. | Complement C5. | 0.992 |
| C6 | C8A | ENSOCUP00000048038 | ENSOCUP00000032867 | Complement C6. | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | 0.945 |
